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MedKoo Cat#: 127536 | Name: NT-0249
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NT-0249 is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity.

Chemical Structure

NT-0249
NT-0249
CAS#2763617-39-4

Theoretical Analysis

MedKoo Cat#: 127536

Name: NT-0249

CAS#: 2763617-39-4

Chemical Formula: C22H28N5NaO4S

Exact Mass: 481.1760

Molecular Weight: 481.55

Elemental Analysis: C, 54.87; H, 5.86; N, 14.54; Na, 4.77; O, 13.29; S, 6.66

Price and Availability

Size Price Availability Quantity
50mg USD 1,250.00 2 Weeks
100mg USD 2,050.00 2 Weeks
1g USD 4,950.00 2 Weeks
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Related CAS #
No Data
Synonym
NT-0249; NT 0249; NT0249
IUPAC/Chemical Name
sodium (S)-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)(N-(1-methyl-1H-pyrazol-4-yl)-N-((tetrahydrofuran-2-yl)methyl)sulfamoyl)amide
InChi Key
VIQOIGVHQODXOY-FERBBOLQSA-M
InChi Code
InChI=1S/C22H29N5O4S.Na/c1-26-13-17(12-23-26)27(14-18-7-4-10-31-18)32(29,30)25-22(28)24-21-19-8-2-5-15(19)11-16-6-3-9-20(16)21;/h11-13,18H,2-10,14H2,1H3,(H2,24,25,28);/q;+1/p-1/t18-;/m0./s1
SMILES Code
O=C([N-]S(N(C1=CN(C)N=C1)C[C@@H]2CCCO2)(=O)=O)NC3=C4C(CCC4)=CC5=C3CCC5.[Na+]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
NLRP3 inhibitor
In vitro activity:
NT-0249 also is evaluated in two acute in vivo mouse challenge models where pharmacodynamic/pharmacokinetic relationships align well with in vitro blood potency assessments. The therapeutic utility of NT-0249 is established in a mouse model of cryopyrin-associated periodic syndrome (CAPS). Reference: Doedens JR, Smolak P, Nguyen M, Wescott H, Diamond C, Schooley K, Billinton A, Harrison D, Koller BH, Watt AP, Gabel CA. Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework. ACS Pharmacol Transl Sci. 2024 Apr 18;7(5):1438-1456. doi: 10.1021/acsptsci.4c00061. PMID: 38751618; PMCID: PMC11091978.
In vivo activity:
NT-0249 also is evaluated in two acute in vivo mouse challenge models where pharmacodynamic/pharmacokinetic relationships align well with in vitro blood potency assessments. The therapeutic utility of NT-0249 is established in a mouse model of cryopyrin-associated periodic syndrome (CAPS). NT-0249 decreased mature IL-1β levels in tissue homogenates, confirming in vivo target engagement. Reference: Doedens JR, Smolak P, Nguyen M, Wescott H, Diamond C, Schooley K, Billinton A, Harrison D, Koller BH, Watt AP, Gabel CA. Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1H-pyrazol-4-yl)({[(2S)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework. ACS Pharmacol Transl Sci. 2024 Apr 18;7(5):1438-1456. doi: 10.1021/acsptsci.4c00061. PMID: 38751618; PMCID: PMC11091978.

Preparing Stock Solutions

The following data is based on the product molecular weight 481.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Thornton P, Reader V, Digby Z, Smolak P, Lindsay N, Harrison D, Clarke N, Watt AP. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024 Feb 15;388(3):813-826. doi: 10.1124/jpet.123.002013. PMID: 38336379.