MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 528315 | Name: Oxeglitazar

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxeglitazar, also known as EMD-336340 and LM-4156, is a peroxisome proliferator-activated receptor (PPAR) agonist potentially for the treatment of gout and type two diabetes.

Chemical Structure

Oxeglitazar
Oxeglitazar
CAS#280585-34-4

Theoretical Analysis

MedKoo Cat#: 528315

Name: Oxeglitazar

CAS#: 280585-34-4

Chemical Formula: C19H22O4

Exact Mass: 314.1518

Molecular Weight: 314.38

Elemental Analysis: C, 72.59; H, 7.05; O, 20.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Oxeglitazar; EMD-336340; EMD336340; EMD 336340; LM-4156; LM 4156; LM4156
IUPAC/Chemical Name
(2E,4E)-5-(7-methoxy-3,3-dimethyl-2,3-dihydrobenzo[b]oxepin-5-yl)-3-methylpenta-2,4-dienoic acid
InChi Key
FVGXANXBVWECQE-BYWGDBCOSA-N
InChi Code
InChI=1S/C19H22O4/c1-13(9-18(20)21)5-6-14-11-19(2,3)12-23-17-8-7-15(22-4)10-16(14)17/h5-11H,12H2,1-4H3,(H,20,21)/b6-5+,13-9+
SMILES Code
O=C(O)/C=C(C)/C=C/C1=CC(C)(C)COC2=CC=C(OC)C=C12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kalivoda A, Fischbach M, Kleinebudde P. Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion. Int J Pharm. 2012 Dec 15;439(1-2):145-56. doi: 10.1016/j.ijpharm.2012.10.013. PubMed PMID: 23073606. 2: Badens E, Majerik V, Horváth G, Szokonya L, Bosc N, Teillaud E, Charbit G. Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies. Int J Pharm. 2009 Jul 30;377(1-2):25-34. doi: 10.1016/j.ijpharm.2009.04.047. PubMed PMID: 19442711. 3: Majerik V, Horváth G, Szokonya L, Charbit G, Badens E, Bosc N, Teillaud E. Supercritical antisolvent versus coevaporation: preparation and characterization of solid dispersions. Drug Dev Ind Pharm. 2007 Sep;33(9):975-83. PubMed PMID: 17891584.