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MedKoo Cat#: 596305 | Name: JTC-017

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JTC-017 is a Corticotropin-releasing hormone receptor 1 antagonist.

Chemical Structure

JTC-017
JTC-017
CAS#357330-77-9

Theoretical Analysis

MedKoo Cat#: 596305

Name: JTC-017

CAS#: 357330-77-9

Chemical Formula: C20H25Cl2N3O5S

Exact Mass: 489.0892

Molecular Weight: 490.39

Elemental Analysis: C, 48.98; H, 5.14; Cl, 14.46; N, 8.57; O, 16.31; S, 6.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JTC-017; JTC 017; JTC017;
IUPAC/Chemical Name
3,5-dichloro-N-(5-(N,N-diethylsulfamoyl)-3-(dimethylamino)-2-methoxyphenyl)-4-hydroxybenzamide
InChi Key
DFHUSLVYQHBBEV-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H25Cl2N3O5S/c1-6-25(7-2)31(28,29)13-10-16(19(30-5)17(11-13)24(3)4)23-20(27)12-8-14(21)18(26)15(22)9-12/h8-11,26H,6-7H2,1-5H3,(H,23,27)
SMILES Code
O=C(NC1=CC(S(=O)(N(CC)CC)=O)=CC(N(C)C)=C1OC)C2=CC(Cl)=C(O)C(Cl)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 490.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saito K, Kasai T, Nagura Y, Ito H, Kanazawa M, Fukudo S. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005 Nov;129(5):1533-43. PubMed PMID: 16285953. 2: Uetsuki N, Segawa H, Mayahara T, Fukuda K. The role of CRF1 receptors for sympathetic nervous response to laparotomy in anesthetized rats. Brain Res. 2005 May 17;1044(1):107-15. Epub 2005 Apr 13. PubMed PMID: 15862795.

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