Tagitinim | CAS#59979-56-5 | antitrypanosomal compound

MedKoo Cat#: 462017 | Name: Tagitinim C

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tagitinim C is an antitrypanosomal compound from the moon flower, Tithonia diversifolia.

Chemical Structure

Tagitinim C

CAS#59979-56-5

Theoretical Analysis

MedKoo Cat#: 462017

Name: Tagitinim C

CAS#: 59979-56-5

Chemical Formula: C19H24O6

Exact Mass: 348.1573

Molecular Weight: 348.40

Elemental Analysis: C, 65.50; H, 6.94; O, 27.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Tagitinim C

IUPAC/Chemical Name

Propanoic acid, 2-methyl-, 2,3,3a,4,5,6,9,11a-octahydro-6-hydroxy-6,10-dimethyl-3-methylene-2,9-dioxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*,6R*,7E,10Z,11aR*))-

InChi Key

DUQSSEQKLJQACA-FESGBCJUSA-N

InChi Code

InChI=1S/C19H24O6/c1-10(2)17(21)25-15-9-19(5,23)7-6-13(20)11(3)8-14-16(15)12(4)18(22)24-14/h6-8,10,14-16,23H,4,9H2,1-3,5H3/b7-6+,11-8-/t14-,15-,16+,19+/m1/s1

SMILES Code

CC(C)C(O[C@@H]([C@](C1=C)([H])[C@]2([H])OC1=O)C[C@@](C)(O)/C=C/C(/C(C)=C\2)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 348.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell Imaniar Ranti, Mae Sri Hartati Wahyuningsih, Yohannes Widodo Wirohadidjojo Pan Afr Med J. 2018; 30: 264. Published online 2018 Aug 8. doi: 10.11604/pamj.2018.30.264.9994 PMCID: PMC6317294 2: Bioassay-Guided Isolation of an Anti-Ulcer Compound, Tagitinin C, from Tithonia diversifolia: Role of Nitric Oxide, Prostaglandins and Sulfhydryls María Elena Sánchez-Mendoza, Adelfo Reyes-Ramírez, Leticia Cruz Antonio, Luis Martínez Jiménez, Juan Rodríguez-Silverio, Jesús Arrieta Molecules. 2011 Jan; 16(1): 665–674. Published online 2011 Jan 17. doi: 10.3390/molecules16010665 PMCID: PMC6259118 3: Comparison of Ultrasound-assisted Extraction and Dynamic Maceration Over Content of Tagitinin C obtained from Tithonia diversifolia (Hemsl.) A. Gray Leaves Using Factorial Design Aline M. R. Silva, Nayara L. O. Ferreira, Anselmo E. Oliveira, Leonardo L. Borges, Edemilson C. Conceição Pharmacogn Mag. 2017 Apr-Jun; 13(50): 270–274. Published online 2017 Apr 18. doi: 10.4103/0973-1296.204555 MCID: PMC5421425 4: A comprehensive study of the potential phytomedicinal use and toxicity of invasive Tithonia species in South Africa Aitebiremen Gift Omokhua, Muna Ali Abdalla, Johannes Van Staden, Lyndy Joy McGaw BMC Complement Altern Med. 2018; 18: 272. Published online 2018 Oct 3. doi: 10.1186/s12906-018-2336-0 PMCID: PMC6171246 5: Effect of the environment on the secondary metabolic profile of Tithonia diversifolia: a model for environmental metabolomics of plants Bruno Leite Sampaio, RuAngelie Edrada-Ebel, Fernando Batista Da Costa Sci Rep. 2016; 6: 29265. Published online 2016 Jul 7. doi: 10.1038/srep29265 PMCID: PMC4935878 6: Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs Moon Nyeo Park, Hyo Sook Song, Myungsun Kim, Min-Jung Lee, Whisung Cho, Hyun-Jin Lee, Cho-Hyun Hwang, Soojong Kim, Yechae Hwang, Beomku Kang, Bonglee Kim Biomed Res Int. 2017; 2017: 8139848. Published online 2017 Oct 18. doi: 10.1155/2017/8139848 PMCID: PMC5664208 7: Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India Sujogya Kumar Panda, Walter Luyten Parasite. 2018; 25: 10. Published online 2018 Mar 12. doi: 10.1051/parasite/2018008 PMCID: PMC5847338 8: In Vitro Leishmanicidal Activities of Sesquiterpene Lactones from Tithonia diversifolia against Leishmania braziliensis Promastigotes and Amastigotes Juliano S. de Toledo, Sergio R. Ambrósio, Carly H. G. Borges, Viviane Manfrim, Daniel G. Cerri, Angela K. Cruz, Fernando B. Da Costa Molecules. 2014 May; 19(5): 6070–6079. Published online 2014 May 14. doi: 10.3390/molecules19056070 PMCID: PMC6271005 9: A Metabolomic Approach to Target Compounds from the Asteraceae Family for Dual COX and LOX Inhibition Daniela A. Chagas-Paula, Tong Zhang, Fernando B. Da Costa, RuAngelie Edrada-Ebel Metabolites. 2015 Sep; 5(3): 404–430. Published online 2015 Jul 8. doi: 10.3390/metabo5030404 PMCID: PMC4588803 10: Extracts from Field Margin Weeds Provide Economically Viable and Environmentally Benign Pest Control Compared to Synthetic Pesticides Prisila Mkenda, Regina Mwanauta, Philip C. Stevenson, Patrick Ndakidemi, Kelvin Mtei, Steven R. Belmain PLoS One. 2015; 10(11): e0143530. Published online 2015 Nov 23. doi: 10.1371/journal.pone.0143530 PMCID: PMC4658159