Synonym
cFMS Receptor Inhibitor II; BUN60856; BUN-60856; BUN 60856;
IUPAC/Chemical Name
4-[(3,4-Dimethylphenyl)amino]-7-(4-pyridinyl)-3-quinolinecarboxamide
InChi Key
BIICXZWYHQOUEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H20N4O/c1-14-3-5-18(11-15(14)2)27-22-19-6-4-17(16-7-9-25-10-8-16)12-21(19)26-13-20(22)23(24)28/h3-13H,1-2H3,(H2,24,28)(H,26,27)
SMILES Code
O=C(C1=C(NC2=CC=C(C)C(C)=C2)C3=CC=C(C4=CC=NC=C4)C=C3N=C1)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
368.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Compositions and methods for obtaining enriched mesenchymal stem cell cultures. By Short, Brenton John; Duronio, Christopher. From U.S. Pat. Appl. Publ. (2016), US 20160032248 A1 20160204.
2. Preparation of enriched mesenchymal stem cell cultures using CSF1R kinase inhibitors. By Short, Brenton John; Duronio, Christopher. From PCT Int. Appl. (2014), WO 2014138888 A1 20140918.
3. 3D-QSAR analysis of anilinoquinoline inhibitors of colony stimulating factor-1 kinase (cFMS): implementation of field-based molecular alignment
By Kumari, Archana; Kaur, Maninder; Bahia, Malkeet Singh; Silakari, Om. From Medicinal Chemistry Research (2013), 22(11), 5167-5183.
4. Synthesis of novel anilinoquinolines as c-fms inhibitors. By Smalley, Terrence L.; Chamberlain, Stanley D.; Mills, Wendy Y.; Musso, David L.; Randhawa, Sab A.; Ray, John A.; Samano, Vicente; Frick, Lloyd. From Bioorganic & Medicinal Chemistry Letters (2007), 17(22), 6257-6260.
