IUPAC/Chemical Name
3-(benzo[d][1,3]dioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChi Key
FTBGFGQPUMCUSC-UHFFFAOYSA-N
InChi Code
1S/C21H18O6/c1-11(2)3-5-13-15(22)8-18-19(20(13)23)21(24)14(9-25-18)12-4-6-16-17(7-12)27-10-26-16/h3-4,6-9,22-23H,5,10H2,1-2H3
SMILES Code
CC(C)=CCC1=C(O)C=C2OC=C(C(=O)C2=C1O)C3=CC=C4OCOC4=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
366.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS. Derrubone, an inhibitor of the Hsp90 protein folding machinery. J Nat Prod. 2007 Dec;70(12):2014-8. doi: 10.1021/np070190s. Epub 2007 Nov 17. PMID: 18020309.
2: Hastings JM, Hadden MK, Blagg BS. Synthesis and evaluation of derrubone and select analogues. J Org Chem. 2008 Jan 18;73(2):369-73. doi: 10.1021/jo702366g. Epub 2007 Dec 22. PMID: 18154304.
3: Liu Y, Zhu ZX, Lu Y, Wang C, Liu HC, Meng J, Qi J, Huang XN, Lu XM, Lu WS, Luo SH, Liang HN, Luo L, Yang LF. A new isoflavone from the stems of Derris eriocarpa How. Nat Prod Res. 2023 Oct 9:1-8. doi: 10.1080/14786419.2023.2265036. Epub ahead of print. PMID: 37812182.
4: Mays JR, Hill SA, Moyers JT, Blagg BS. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. Bioorg Med Chem. 2010 Jan 1;18(1):249-66. doi: 10.1016/j.bmc.2009.10.061. Epub 2009 Oct 31. PMID: 19932969; PMCID: PMC2818389.
5: Tantapakul C, Suthiphasilp V, Payaka A, Chaiyosang B, Harding DJ, Phuphong W, Tontapha S, Laphookhieo S. Derrisrobustones A-D, isoflavones from the twig extract of Derris robusta (DC.) Benth. and their α-glucosidase inhibitory activity. Phytochemistry. 2022 Jun;198:113168. doi: 10.1016/j.phytochem.2022.113168. Epub 2022 Mar 21. PMID: 35331731.
6: Khalid S, Paul S. Identifying a C-terminal ATP binding sites-based novel Hsp90-Inhibitor in silico: a plausible therapeutic approach in Alzheimer's disease. Med Hypotheses. 2014 Jul;83(1):39-46. doi: 10.1016/j.mehy.2014.04.013. Epub 2014 Apr 13. PMID: 24785461.
7: Ito C, Matsui T, Miyabe K, Hasan CM, Rashid MA, Tokuda H, Itoigawa M. Three isoflavones from Derris scandens (Roxb.) Benth and their cancer chemopreventive activity and in vitro antiproliferative effects. Phytochemistry. 2020 Jul;175:112376. doi: 10.1016/j.phytochem.2020.112376. Epub 2020 Apr 15. PMID: 32304910.
8: Tomar JS. In-silico modeling studies of G-quadruplex with soy isoflavones having anticancerous activity. J Mol Model. 2015 Aug;21(8):193. doi: 10.1007/s00894-015-2723-0. Epub 2015 Jul 12. PMID: 26164556.
