MedKoo Cat#: 573161 | Name: Nifenazone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nifenazone is a drug used as an analgesic for a number of rheumatic conditions.

Chemical Structure

Nifenazone
CAS#2139-47-1

Theoretical Analysis

MedKoo Cat#: 573161

Name: Nifenazone

CAS#: 2139-47-1

Chemical Formula: C17H16N4O2

Exact Mass: 308.1273

Molecular Weight: 308.34

Elemental Analysis: C, 66.22; H, 5.23; N, 18.17; O, 10.38

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Related CAS #
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Synonym
N-Antipyrinylnicotinamide, Niapyrin, Nicazane, Nicodon, Nicodone, Nicofesone, Nicophesone, Nicophezon, Nicopyron, Nicoreumal, Nicoron, Nicotazone, Nifenazone
IUPAC/Chemical Name
Nicotinamide, N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-
InChi Key
BRZANEXCSZCZCI-UHFFFAOYSA-N
InChi Code
1S/C17H16N4O2/c1-12-15(19-16(22)13-7-6-10-18-11-13)17(23)21(20(12)2)14-8-4-3-5-9-14/h3-11H,1-2H3,(H,19,22)
SMILES Code
Cc1c(c(=O)n(n1C)c2ccccc2)NC(=O)c3cccnc3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Biological target:
Nifenazone is a pyrazole drug which can be used in the in the treatment of a variety of rheumatic disorders.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
Water 2.0 6.49
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 308.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Bani-Yaseen AD, Al-Balawi M. The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study. Phys Chem Chem Phys. 2014 Aug 7;16(29):15519-26. doi: 10.1039/c4cp01679c. Epub 2014 Jun 23. PubMed PMID: 24954054. 2: Beyer KH, Friese J. [Nifenazone, biotransformation in humans]. Arch Pharm (Weinheim). 1985 Sep;318(9):855-63. German. PubMed PMID: 2935118. 3: Gola A, Galazka Z, Szczeklik A. Evaluation of liver function during administration of nifenazone in rheumatic disease on the basis of serum protein studies and enzyme tests. Mater Med Pol. 1972 Apr-Jun;4(2):66-70. PubMed PMID: 4270064. 4: HART FD, BOARDMAN PL. TRIAL OF NIFENAZONE ("THYLIN"). Br Med J. 1964 Jun 13;1(5397):1553-4. PubMed PMID: 14133613; PubMed Central PMCID: PMC1814611.