MedKoo Cat#: 150136 | Name: Bromhexine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bromhexine is used for conditions where there are a lot of thick mucus in the airways. Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells. Bromhexine disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces a less viscous mucus, which is easier to expectorate.

Chemical Structure

Bromhexine
Bromhexine
CAS#3572-43-8 (free base)

Theoretical Analysis

MedKoo Cat#: 150136

Name: Bromhexine

CAS#: 3572-43-8 (free base)

Chemical Formula: C14H20Br2N2

Exact Mass: 373.9990

Molecular Weight: 376.14

Elemental Analysis: C, 44.71; H, 5.36; Br, 42.49; N, 7.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Bromhexine; Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-; Bromhexina; Bromhexinum;
IUPAC/Chemical Name
Benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-
InChi Key
OJGDCBLYJGHCIH-UHFFFAOYSA-N
InChi Code
1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3
SMILES Code
CN(CC1=C(N)C(Br)=CC(Br)=C1)C2CCCCC2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Deretic V, Timmins GS. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. doi: 10.1080/17425255.2019.1578748. Epub 2019 Feb 7. PMID: 30721101; PMCID: PMC6947664. 2: Tolouian R, Mulla ZD, Jamaati H, Babamahmoodi A, Marjani M, Eskandari R, Dastan F. Effect of bromhexine in hospitalized patients with COVID-19. J Investig Med. 2023 Oct;71(7):691-699. doi: 10.1136/jim-2020-001747. PMID: 33722999. 3: Gholami A, Minai-Tehrani D, Eftekhar F. Bromhexine and its inhibitory effect on lipase - kinetics and structural study. Arch Physiol Biochem. 2022 Dec;128(6):1687-1692. doi: 10.1080/13813455.2020.1788606. Epub 2020 Jul 7. PMID: 32633559.