Bromhexine HCl | CAS#611-75-6 | CAS#3572-43-8 | Synthetic Vasicine Derivative

MedKoo Cat#: 540051 | Name: Bromhexine HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bromhexine HCl is a synthetic vasicine derivative used to treat mucus-related respiratory disorders. It increases production of serous mucus, decrease mucus viscosity and helps cilia transport mucus out of the lungs.

Chemical Structure

Bromhexine HCl

CAS#611-75-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 540051

Name: Bromhexine HCl

CAS#: 611-75-6 (HCl)

Chemical Formula: C14H21Br2ClN2

Exact Mass: 0.0000

Molecular Weight: 412.59

Elemental Analysis: C, 40.76; H, 5.13; Br, 38.73; Cl, 8.59; N, 6.79

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

611-75-6 (HCl) 3572-43-8 (free base)

Synonym

Bromessina; Broncokin; Lisomucin; NA 274; NA-274; NA274

IUPAC/Chemical Name

2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

InChi Key

UCDKONUHZNTQPY-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H

SMILES Code

CN(C1CCCCC1)CC2=CC(Br)=CC(Br)=C2N.[H]Cl

Appearance

White to off-white crystalline powder.

Purity

>97% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 412.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Solubility and solution stability studies of different amino acid prodrugs of bromhexine. Drug Dev Ind Pharm. 2012 Nov;38(11):1319-27. Epub 2012 Jan 28. PubMed PMID: 22283553. 9: Stojanov M, Nielsen HM, Larsen KL. Cyclodextrins: Efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems. Int J Pharm. 2012 Jan 17;422(1-2):349-55. doi: 10.1016/j.ijpharm.2011.10.023. Epub 2011 Oct 17. PubMed PMID: 22027391. 10: Azodi-Deilami S, Abdouss M, Javanbakht M. The syntheses and characterization of molecularly imprinted polymers for the controlled release of bromhexine. Appl Biochem Biotechnol. 2011 May;164(2):133-47. doi: 10.1007/s12010-010-9121-y. Epub 2010 Nov 14. PubMed PMID: 21076945. 11: Vide J, Moreira C, Cunha AP, Baldaia H, Magina S, Azevedo F. Generalized Bullous Fixed Drug Eruption due to Bromhexine. Dermatol Online J. 2016 Jul 15;22(7). pii: 13030/qt7nt074w4. PubMed PMID: 27617726. 12: Liu J, Chen X, Hu Y, Cheng G, Zhong D. 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