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MedKoo Cat#: 161005 | Name: PYRACLOFOS

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PYRACLOFOS is an organophosphorus pesticide. PYRACLOFOS is an acetylcholinesterase inhibitor. Different enantiomers of PYRACLOFOS have varying levels of toxicity in soil exposure.

Chemical Structure

PYRACLOFOS
PYRACLOFOS
CAS#89784-60-1

Theoretical Analysis

MedKoo Cat#: 161005

Name: PYRACLOFOS

CAS#: 89784-60-1

Chemical Formula: C14H18ClN2O3PS

Exact Mass: 360.0500

Molecular Weight: 360.79

Elemental Analysis: C, 46.61; H, 5.03; Cl, 9.83; N, 7.76; O, 13.30; P, 8.58; S, 8.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PYRACLOFOS;
IUPAC/Chemical Name
O-(1-(4-chlorophenyl)-1H-pyrazol-4-yl) O-ethyl S-propyl phosphorothioate
InChi Key
QHGVXILFMXYDRS-UHFFFAOYSA-N
InChi Code
1S/C14H18ClN2O3PS/c1-3-9-22-21(18,19-4-2)20-14-10-16-17(11-14)13-7-5-12(15)6-8-13/h5-8,10-11H,3-4,9H2,1-2H3
SMILES Code
CCCSP(=O)(OCC)OC1=CN(N=C1)C2=CC=C(Cl)C=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 360.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Peng W, Wang T, Liang XR, Yang YS, Wang QZ, Cheng HF, Peng YK, Ding F. Characterizing the potentially neuronal acetylcholinesterase reactivity toward chiral pyraclofos: Enantioselective insights from spectroscopy, in silico docking, molecular dynamics simulation and per-residue energy decomposition studies. J Mol Graph Model. 2022 Jan;110:108069. doi: 10.1016/j.jmgm.2021.108069. Epub 2021 Nov 1. PMID: 34773872. 2: Zhuang S, Zhang Z, Zhang W, Bao L, Xu C, Zhang H. Enantioselective developmental toxicity and immunotoxicity of pyraclofos toward zebrafish (Danio rerio). Aquat Toxicol. 2015 Feb;159:119-26. doi: 10.1016/j.aquatox.2014.12.006. Epub 2014 Dec 12. PMID: 25540855. 3: Ishimota M, Tajiki-Nishino R, Fukuyama T, Tomiyama N. Rapid adaptation of Chironomus yoshimatsui to acetylcholinesterase inhibitors (pyraclofos and pirimicarb) in a multi-generation study. J Environ Sci Health B. 2020;55(5):429-437. doi: 10.1080/03601234.2019.1708165. Epub 2020 Feb 17. PMID: 32065017. 4: Xu Y, Zhang H, Zhuang S, Yu M, Xiao H, Qian M. Different enantioselective degradation of pyraclofos in soils. J Agric Food Chem. 2012 May 2;60(17):4173-8. doi: 10.1021/jf205189v. Epub 2012 Apr 24. PMID: 22494269. 5: Zhang H, Chen S, Zhou S. Enantiomeric separation and toxicity of an organophosporus insecticide, pyraclofos. J Agric Food Chem. 2012 Jul 18;60(28):6953-9. doi: 10.1021/jf3015427. Epub 2012 Jul 3. PMID: 22708718. 6: Seok SH, Park JH, Cho SA, Kim DJ, Bae BK, Park JH. Risk assessment of the organophosphate pesticides isazofos and pyraclofos using a 21-day dietary toxicity study in Japanese quail. Ecotoxicol Environ Saf. 2008 Sep;71(1):245-51. doi: 10.1016/j.ecoenv.2007.05.015. Epub 2007 Jul 16. PMID: 17629558. 7: Yang H, Xue B, Li L, Zhou S, Tu Y, Lin C. Hydrolysis and soil sorption of insecticide pyraclofos. J Environ Sci Health B. 2008 Mar-Apr;43(3):219-23. doi: 10.1080/10934520701792662. PMID: 18368541. 8: Al Mahmud MN, Rahman M, Na TW, Park JH, Yang A, Park KH, Abd El-Aty AM, Nahar N, Shim JH. A QuEChERS-based extraction method for the residual analysis of pyraclofos and tebufenpyrad in perilla leaves using gas chromatography: application to dissipation pattern. Biomed Chromatogr. 2013 Feb;27(2):156-63. doi: 10.1002/bmc.2763. Epub 2012 Jun 25. PMID: 22733570. 9: Wu KH, Huang WC, Chang SC, Shyu RH. Colloidal silver-based lateral flow immunoassay for detection of profenofos pesticide residue in vegetables. RSC Adv. 2022 Apr 29;12(21):13035-13044. doi: 10.1039/d2ra01654k. PMID: 35497005; PMCID: PMC9052933. 10: Sahu SS. Hut-scale trial of pyraclofos against malaria vectors in Malkangiri District of Orissa. Indian J Malariol. 1996 Mar;33(1):16-20. PMID: 8690128.

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