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MedKoo Cat#: 145351 | Name: CP-94253

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-94253is a 5-HT1B agonist. CP 94253 (2.5-10 mg/kg) significantly reduces the axillary temperatures of preweanling and adult rats. CP 94253 significantly decreases the locomotor activity of male and female adult rats, while CP 94253 does not affect the locomotor activity of PD 15 rats. CP 94253 exerts anticonvulsant activity on pentylenetetrazol-induced seizures in mice.

Chemical Structure

CP-94253
CP-94253
CAS#131084-35-0 (free base)

Theoretical Analysis

MedKoo Cat#: 145351

Name: CP-94253

CAS#: 131084-35-0 (free base)

Chemical Formula: C15H19N3O

Exact Mass: 257.1528

Molecular Weight: 257.34

Elemental Analysis: C, 70.01; H, 7.44; N, 16.33; O, 6.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
845861-39-4 (HCl) 131084-35-0 (free base)
Synonym
CP-94253; CP94253; CP 94253;
IUPAC/Chemical Name
5-propoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[3,2-b]pyridine
InChi Key
KWQWBZIGHIOKIO-UHFFFAOYSA-N
InChi Code
1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3
SMILES Code
CCCOC1=CC=C2NC=C(C2=N1)C3=CCNCC3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 257.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Monti JM. Serotonin control of sleep-wake behavior. Sleep Med Rev. 2011 Aug;15(4):269-81. doi: 10.1016/j.smrv.2010.11.003. Epub 2011 Apr 2. PMID: 21459634. 2: McDougall SA, Taylor JA, Roe MJ, Greenwood CJ. Effects of repeated treatment with the 5-HT1A and 5-HT1B agonists (R)-( +)-8-hydroxy- DPAT and CP-94253 on the locomotor activity and axillary temperatures of preweanling rats: evidence of tolerance and behavioral sensitization. Psychopharmacology (Berl). 2022 Feb;239(2):413-427. doi: 10.1007/s00213-021-06012-5. Epub 2021 Nov 24. PMID: 34816290. 3: McDougall SA, Roe MJ, Robinson JAM, Cotter LL, Gonzalez DJ, Gleason DC, Crawford CA. Effects of the serotonin 5-HT1B receptor agonist CP 94253 on the locomotor activity and body temperature of preweanling and adult male and female rats. Eur J Pharmacol. 2022 Jul 5;926:175019. doi: 10.1016/j.ejphar.2022.175019. Epub 2022 May 10. PMID: 35561752. 4: Wesołowska A, Nikiforuk A, Chojnacka-Wójcik E. Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice. Eur J Pharmacol. 2006 Jul 10;541(1-2):57-63. doi: 10.1016/j.ejphar.2006.04.049. Epub 2006 May 7. PMID: 16765343. 5: Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka- Wójcik E. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. Eur J Pharmacol. 2005 May 23;516(1):46-50. doi: 10.1016/j.ejphar.2005.04.025. PMID: 15913599. 6: Monti JM, Jantos H, Lagos P. Activation of serotonin 5-HT(1B) receptor in the dorsal raphe nucleus affects REM sleep in the rat. Behav Brain Res. 2010 Jan 5;206(1):8-16. doi: 10.1016/j.bbr.2009.08.037. Epub 2009 Sep 6. PMID: 19737581. 7: Tatarczyńska E, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression. Behav Pharmacol. 2004 Dec;15(8):523-34. doi: 10.1097/00008877-200412000-00001. PMID: 15577451. 8: Skelin I, Kovačević T, Sato H, Diksic M. The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression. Brain Res Bull. 2012 Aug 1;88(5):477-86. doi: 10.1016/j.brainresbull.2012.04.009. Epub 2012 Apr 20. PMID: 22542420; PMCID: PMC3653842. 9: Hayes DJ, Graham DA, Greenshaw AJ. Effects of systemic 5-HT(1B) receptor compounds on ventral tegmental area intracranial self-stimulation thresholds in rats. Eur J Pharmacol. 2009 Feb 14;604(1-3):74-8. doi: 10.1016/j.ejphar.2008.12.023. Epub 2008 Dec 24. PMID: 19135047. 10: Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M. Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self- administration in rats. Eur J Pharmacol. 2007 Mar 22;559(2-3):165-72. doi: 10.1016/j.ejphar.2006.12.012. Epub 2007 Jan 16. PMID: 17291490. 11: Lee MD, Simansky KJ. CP-94, 253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology (Berl). 1997 Jun;131(3):264-70. doi: 10.1007/s002130050292. PMID: 9203237. 12: Miszkiel J, Przegaliński E. Effects of serotonin (5-HT)1B receptor ligands on amphetamine-seeking behavior in rats. Pharmacol Rep. 2013;65(4):813-22. doi: 10.1016/s1734-1140(13)71062-4. PMID: 24145075. 13: Miszkiel J, Adamczyk P, Filip M, Przegaliński E. The effect of serotonin 5HT1B receptor ligands on amphetamine self-administration in rats. Eur J Pharmacol. 2012 Feb 29;677(1-3):111-5. doi: 10.1016/j.ejphar.2011.12.033. Epub 2011 Dec 29. PMID: 22227331. 14: Stamford JA, Davidson C, McLaughlin DP, Hopwood SE. Control of dorsal raphé 5-HT function by multiple 5-HT(1) autoreceptors: parallel purposes or pointless plurality? Trends Neurosci. 2000 Oct;23(10):459-65. doi: 10.1016/s0166-2236(00)01631-3. PMID: 11006462. 15: McDevitt RA, Hiroi R, Mackenzie SM, Robin NC, Cohn A, Kim JJ, Neumaier JF. Serotonin 1B autoreceptors originating in the caudal dorsal raphe nucleus reduce expression of fear and depression-like behavior. Biol Psychiatry. 2011 Apr 15;69(8):780-7. doi: 10.1016/j.biopsych.2010.12.029. Epub 2011 Feb 26. PMID: 21353664; PMCID: PMC3080128. 16: Chojnacka-Wójcik E, Kłodzińska A, Tatarczyńska E. The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action. J Pharm Pharmacol. 2005 Feb;57(2):253-7. doi: 10.1211/0022357055399. PMID: 15720791. 17: Przegaliński E, Gołda A, Filip M. Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats. Pharmacol Rep. 2008 Nov- Dec;60(6):798-810. PMID: 19211971. 18: Miczek KA, Fish EW, De Bold JF, De Almeida RM. Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems. Psychopharmacology (Berl). 2002 Oct;163(3-4):434-58. doi: 10.1007/s00213-002-1139-6. Epub 2002 Aug 6. 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