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MedKoo Cat#: 145335 | Name: ST-1936

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ST-1936 is a new 5-HT(6) receptor agonist. 5-HT6 receptor activation by ST1936 reduces the frequency of spontaneous excitatory postsynaptic currents. ST1936 reduced the frequency, but not the amplitude, of spontaneous excitatory postsynaptic currents suggesting a presynaptic or indirect effect of the 5-HT6 receptor.

Chemical Structure

ST-1936
CAS#1210-81-7

Theoretical Analysis

MedKoo Cat#: 145335

Name: ST-1936

CAS#: 1210-81-7

Chemical Formula: C13H17ClN2

Exact Mass: 236.1080

Molecular Weight: 236.74

Elemental Analysis: C, 65.95; H, 7.24; Cl, 14.97; N, 11.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ST-1936; ST1936; ST 1936;
IUPAC/Chemical Name
2-(5-chloro-2-methyl-1H-indol-3-yl)-N,N-dimethylethan-1-amine
InChi Key
KSYMELKKLOFABL-UHFFFAOYSA-N
InChi Code
1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3
SMILES Code
CN(C)CCC1=C(C)NC2=CC=C(Cl)C=C12
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 236.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Scheggi S, Marchese G, Borsini F, Bordi F, De Montis MG. Effects of the 5-HT(6) receptor agonist ST 1936 on depression- and anhedonia-like experimental models. Behav Brain Res. 2011 Oct 10;224(1):35-43. doi: 10.1016/j.bbr.2011.05.019. Epub 2011 May 27. PMID: 21645553. 2: Pei Y, Wen X, Guo SC, Yang ZS, Zhang R, Xiao P, Sun JP. Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6. Biochem Biophys Res Commun. 2023 Sep 3;671:327-334. doi: 10.1016/j.bbrc.2023.05.126. Epub 2023 Jun 5. PMID: 37327704. 3: Wang Q, Dong X, Hu T, Qu C, Lu J, Zhou Y, Li J, Pei G. Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors. Stem Cell Reports. 2021 Jan 12;16(1):75-88. doi: 10.1016/j.stemcr.2020.11.015. Epub 2020 Dec 23. PMID: 33357407; PMCID: PMC7815944. 4: Hannan AJ. European Neuroscience--Seventh Biennial FENS Forum. IDrugs. 2010 Sep;13(9):607-9. PMID: 20799140. 5: Tassone A, Madeo G, Schirinzi T, Vita D, Puglisi F, Ponterio G, Borsini F, Pisani A, Bonsi P. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. Neuropharmacology. 2011 Sep;61(4):632-7. doi: 10.1016/j.neuropharm.2011.05.004. Epub 2011 May 19. PMID: 21619890. 6: Valentini V, Piras G, De Luca MA, Perra V, Bordi F, Borsini F, Frau R, Di Chiara G. Evidence for a role of a dopamine/5-HT6 receptor interaction in cocaine reinforcement. Neuropharmacology. 2013 Feb;65:58-64. doi: 10.1016/j.neuropharm.2012.08.025. Epub 2012 Sep 7. Erratum in: Neuropharmacology. 2013 Oct;73:397. PMID: 22982249. 7: Riccioni T, Bordi F, Minetti P, Spadoni G, Yun HM, Im BH, Tarzia G, Rhim H, Borsini F. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. doi: 10.1016/j.ejphar.2011.04.028. Epub 2011 Apr 28. PMID: 21549693. 8: Aldrin-Kirk P, Heuer A, Wang G, Mattsson B, Lundblad M, Parmar M, Björklund T. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor. Neuron. 2016 Jun 1;90(5):955-68. doi: 10.1016/j.neuron.2016.04.017. Epub 2016 May 5. PMID: 27161524; PMCID: PMC4893163. 9: Borsini F, Bordi F, Poggi A, Di Matteo V. Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain. J Psychopharmacol. 2015 Jul;29(7):802-11. doi: 10.1177/0269881115573804. Epub 2015 Mar 3. PMID: 25735994. 10: Valentini V, Frau R, Bordi F, Borsini F, Di Chiara G. A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology. 2011 Mar;60(4):602-8. doi: 10.1016/j.neuropharm.2010.12.006. Epub 2010 Dec 23. PMID: 21185318.