MedKoo Cat#: 208464 | Name: DL-175

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DL-175 is a potent, selective, and structurally novel GPR84 agonist and the first to display significantly biased signaling across GPR84-overexpressing cells, primary murine macrophages, and human U937 cells.

Chemical Structure

DL-175
DL-175
CAS#2487253-25-6

Theoretical Analysis

MedKoo Cat#: 208464

Name: DL-175

CAS#: 2487253-25-6

Chemical Formula: C17H14ClNO2

Exact Mass: 299.0713

Molecular Weight: 299.75

Elemental Analysis: C, 68.12; H, 4.71; Cl, 11.83; N, 4.67; O, 10.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GTPL11213, DL175
IUPAC/Chemical Name
3-(2-((4-Chloronaphthalen-1-yl)oxy)ethyl)pyridine 1-oxide
InChi Key
FXOVKEUUTXBOJZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H14ClNO2/c18-16-7-8-17(15-6-2-1-5-14(15)16)21-11-9-13-4-3-10-19(20)12-13/h1-8,10,12H,9,11H2
SMILES Code
ClC1=C2C=CC=CC2=C(OCCC3=C[N+]([O-])=CC=C3)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 299.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Lucy D, Purvis GSD, Zeboudj L, Chatzopoulou M, Recio C, Bataille CJR, Wynne GM, Greaves DR, Russell AJ. A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages. ACS Chem Biol. 2019 Sep 20;14(9):2055-2064. doi: 10.1021/acschembio.9b00533. Epub 2019 Sep 10. PMID: 31465201.