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MedKoo Cat#: 127458 | Name: GS-646939

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GS-646939 is an antiviral agent.

Chemical Structure

GS-646939
GS-646939
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127458

Name: GS-646939

CAS#: N/A

Chemical Formula: C12H16N5O13P3

Exact Mass: 530.9957

Molecular Weight: 531.20

Elemental Analysis: C, 27.13; H, 3.04; N, 13.18; O, 39.15; P, 17.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GS-646939; GS646939; GS 646939
IUPAC/Chemical Name
((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChi Key
AGRGENULNBECTG-QFOLPQNPSA-N
InChi Code
InChI=1S/C12H16N5O13P3/c13-3-12(4-27-32(23,24)30-33(25,26)29-31(20,21)22)10(19)8(18)9(28-12)6-1-2-7-11(14)15-5-16-17(6)7/h1-2,5,8-10,18-19H,4H2,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t8-,9-,10-,12+/m0/s1
SMILES Code
NC1=NC=NN2C([C@H](O3)[C@H](O)[C@H](O)[C@@]3(C#N)COP(O)(OP(O)(OP(O)(O)=O)=O)=O)=CC=C21
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 531.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Gordon CJ, Walker SM, Tchesnokov EP, Kocincova D, Pitts J, Siegel DS, Perry JK, Feng JY, Bilello JP, Götte M. Mechanism and spectrum of inhibition of a 4´-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses. J Biol Chem. 2024 Jun 28:107514. doi: 10.1016/j.jbc.2024.107514. Epub ahead of print. PMID: 38945449.