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MedKoo Cat#: 564645 | Name: MRL20

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRL20 is a selective PPARγ modulator (SPPARγM) which displays robust anti-diabetic activity with an improved therapeutic window in comparison to a PPARγ full agonist in a rodent efficacy model.

Chemical Structure

MRL20
MRL20
CAS#393794-32-6

Theoretical Analysis

MedKoo Cat#: 564645

Name: MRL20

CAS#: 393794-32-6

Chemical Formula: C28H24F3NO6

Exact Mass: 527.1556

Molecular Weight: 527.50

Elemental Analysis: C, 63.76; H, 4.59; F, 10.80; N, 2.66; O, 18.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MRL-20; MRL 20; MRL20
IUPAC/Chemical Name
(2S)-2-[2-[[1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)indol-3-yl]methyl]phenoxy]propanoic acid
InChi Key
BWTOBMCYVACNJZ-KRWDZBQOSA-N
InChi Code
InChI=1S/C28H24F3NO6/c1-16-22(14-19-6-4-5-7-25(19)37-17(2)27(34)35)23-15-21(38-28(29,30)31)12-13-24(23)32(16)26(33)18-8-10-20(36-3)11-9-18/h4-13,15,17H,14H2,1-3H3,(H,34,35)/t17-/m0/s1
SMILES Code
C[C@H](OC1=CC=CC=C1CC2=C(C)N(C(C3=CC=C(OC)C=C3)=O)C4=C2C=C(OC(F)(F)F)C=C4)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 527.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Brust R, Lin H, Fuhrmann J, Asteian A, Kamenecka TM, Kojetin DJ. Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor. ACS Chem Biol. 2017 Apr 21;12(4):969-978. doi: 10.1021/acschembio.6b01015. Epub 2017 Feb 16. PubMed PMID: 28165718; PubMed Central PMCID: PMC5652320. 2: Shimoyama M, Ohtsu T, Ishida Y, Kuroki Y, Shimada Y, Tobinai K, Minato K, Hamada H, Tsuruo T. [Detection of multidrug resistant phenotype in leukemia and lymphoma by monoclonal antibodies]. Gan To Kagaku Ryoho. 1988 Oct;15(10):2863-70. Japanese. PubMed PMID: 2902832.