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MedKoo Cat#: 145276 | Name: RB-64

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RB-64 is a G protein-biased agonist. RB-64 in a low concentration without β-arrestin recruitment does not reduce LDH release and increase cell viability as observed with SA.

Chemical Structure

RB-64
RB-64
CAS#1174223-49-4

Theoretical Analysis

MedKoo Cat#: 145276

Name: RB-64

CAS#: 1174223-49-4

Chemical Formula: C24H27NO8S

Exact Mass: 489.1457

Molecular Weight: 489.54

Elemental Analysis: C, 58.88; H, 5.56; N, 2.86; O, 26.15; S, 6.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RB-64; RB64; RB 64;
IUPAC/Chemical Name
methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-9-(2-thiocyanatoacetoxy)dodecahydro-2H-benzo[f]isochromene-7-carboxylate
InChi Key
AZPUAKGNQXURGA-ZWLNRFIDSA-N
InChi Code
1S/C24H27NO8S/c1-23-6-4-14-22(29)33-17(13-5-7-31-10-13)9-24(14,2)20(23)19(27)16(8-15(23)21(28)30-3)32-18(26)11-34-12-25/h5,7,10,14-17,20H,4,6,8-9,11H2,1-3H3/t14-,15-,16-,17-,20-,23-,24-/m0/s1
SMILES Code
[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(=O)CSC#N)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)C4=COC=C4)C(=O)OC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 489.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL. The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo. J Pharmacol Exp Ther. 2015 Jan;352(1):98-109. doi: 10.1124/jpet.114.216820. Epub 2014 Oct 15. PMID: 25320048; PMCID: PMC4279099. 2: Mores KL, Cummins BR, Cassell RJ, van Rijn RM. A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists. Front Pharmacol. 2019 Apr 17;10:407. doi: 10.3389/fphar.2019.00407. PMID: 31057409; PMCID: PMC6478756. 3: Emond EC, Groves AM, Hutton BF, Thielemans K. Effect of positron range on PET quantification in diseased and normal lungs. Phys Med Biol. 2019 Oct 16;64(20):205010. doi: 10.1088/1361-6560/ab469d. PMID: 31539891. 4: Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu YT, Spetea M, Liu- Chen LY, Schwarzer C, Mann M. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 2018 Jun 22;360(6395):eaao4927. doi: 10.1126/science.aao4927. PMID: 29930108; PMCID: PMC6527112. 5: Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. Structure of the human κ-opioid receptor in complex with JDTic. Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939. PMID: 22437504; PMCID: PMC3356457. 6: Xu J, Chen F, Wang S, Akins NS, Hossain MI, Zhou Y, Huang J, Ji J, Xi J, Lin W, Grothusen J, Le HV, Liu R. Kappa opioid receptors internalization is protective against oxygen-glucose deprivation through β-arrestin activation and Akt-mediated signaling pathway. Neurochem Int. 2020 Jul;137:104748. doi: 10.1016/j.neuint.2020.104748. Epub 2020 Apr 24. PMID: 32339667; PMCID: PMC7321825. 7: Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL. Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry. 2009 Jul 28;48(29):6898-908. doi: 10.1021/bi900605n. PMID: 19555087; PMCID: PMC2752672. 8: MAIER MH, ANDERSON SB. GROWTH STUDY. I. ADOLESCENT BEHAVIOR AND INTERESTS. CONTRACT NONR 2214(00), NR 151-174, RB-64-52. Protein Alter Erythroc Low Temp. 1964 Oct;59:1-85. PMID: 24547317.

View History

NC-0687

NC-0687