Vemtoberant, also known as APD418, is a β3-adrenergic receptor (AdrR) antagonist for treatment of decompensated heart failure. Unlike current inotrope therapies, Vemtoberant improves cardiac contractility with minimal negative impact on heart rate, blood pressure, and myocardial oxygen consumption. Vemtoberant has undergone Phase 2 trials for those in heart failure with reduced ejection fraction.
MedKoo Cat#: 130062
Name: Vemtoberant
CAS#: 2169905-68-2
Chemical Formula: C29H37N3O8S2
Exact Mass: 619.2022
Molecular Weight: 619.75
Elemental Analysis: C, 56.20; H, 6.02; N, 6.78; O, 20.65; S, 10.35
The following data is based on the product molecular weight 619.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
