Tesevatinib, also known as XL647, EXEL-7647 and KD-019, is a n orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL647 binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression.
MedKoo Cat#: 127406
Name: Tesevatinib tosylate
CAS#: 1000599-06-3 (tosylate)
Chemical Formula: C31H33Cl2FN4O5S
Exact Mass: 662.1533
Molecular Weight: 663.59
Elemental Analysis: C, 56.11; H, 5.01; Cl, 10.68; F, 2.86; N, 8.44; O, 12.05; S, 4.83
The following data is based on the product molecular weight 663.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
