Synonym
SM1044; SM-1044; SM 1044;
IUPAC/Chemical Name
Bis(2-(((3R,6R,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)ethyl)amine
InChi Key
CYJOFOZKQKUVJA-TXWHCHBCSA-N
InChi Code
1S/C34H55NO10/c1-19-7-9-25-21(3)27(38-29-33(25)23(19)11-13-31(5,40-29)42-44-33)36-17-15-35-16-18-37-28-22(4)26-10-8-20(2)24-12-14-32(6)41-30(39-28)34(24,26)45-43-32/h19-30,35H,7-18H2,1-6H3/t19-,20-,21-,22-,23?,24?,25?,26?,27+,28+,29-,30-,31-,32-,33-,34-/m1/s1
SMILES Code
C[C@H]1[C@@H](OCCNCCO[C@H]2O[C@@]3([H])[C@@]4(OO[C@](O3)(C)CC5)C5[C@H](C)CCC4[C@H]2C)O[C@@]6([H])[C@@]7(OO[C@](O6)(C)CC8)C8[C@H](C)CCC17
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
637.81
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li Y, Zeng ZW, Chen D, Gu ZC, Yan WL, Yue LY, Zhu RG, Zhao YL, Chen L, Zhao QJ, He B. Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target. J Med Chem. 2023 Aug 24;66(16):11335-11350. doi: 10.1021/acs.jmedchem.3c00824. Epub 2023 Aug 8. PMID: 37552639.
2: Cheng C, Wang T, Song Z, Peng L, Gao M, Hermine O, Rousseaux S, Khochbin S, Mi JQ, Wang J. Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044. Cancer Med. 2018 Feb;7(2):380-396. doi: 10.1002/cam4.1276. Epub 2017 Dec 26. PMID: 29277967; PMCID: PMC5806110.
3: Liu JJ, Fei AM, Nie RM, Wang J, Li Y, Wang ZY, Mi JQ. [A new artemisinin derivative SM1044 induces apoptosis of Kasumi-1 cells and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun;19(3):607-11. Chinese. PMID: 21729533.
4: Zhu Y, Klausen C, Zhou J, Guo X, Zhang Y, Zhu H, Li Z, Cheng JC, Xie S, Yang W, Li Y, Leung PCK. Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9(1):15528. doi: 10.1038/s41598-019-52108-6. PMID: 31664127; PMCID: PMC6820742.
