V11294A | CAS#162278-10-6 | Inhibitor

MedKoo Cat#: 208249 | Name: V11294A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

V11294A is a novel PDE4 inhibitor. A single oral 300 mg dose of V11294A administered to healthy volunteers results in plasma concentrations adequate to inhibit activation of inflammatory cells ex vivo, which persists for at least 24 h without any adverse reactions

Chemical Structure

V11294A

CAS#162278-10-6

Theoretical Analysis

MedKoo Cat#: 208249

Name: V11294A

CAS#: 162278-10-6

Chemical Formula: C23H32ClN5O2

Exact Mass: 445.2245

Molecular Weight: 445.99

Elemental Analysis: Chemical Formula: C23H32ClN5O2 Exact Mass: 445.2245 Molecular Weight: 445.9920 Elemental Analysis: C, 61.94; H, 7.23; Cl, 7.95; N, 15.70; O, 7.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

V-11294A, V11-294A, V11294-A

IUPAC/Chemical Name

6-Ethylamino-3-(3-Cyclopentyloxy-4-methoxybenzyl)-8-isopropyl-3H-purine hydrochloride

InChi Key

UUAPXPGCDROOPM-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H31N5O2.ClH/c1-5-24-22-20-23(27-21(26-20)15(2)3)28(14-25-22)13-16-10-11-18(29-4)19(12-16)30-17-8-6-7-9-17;/h10-12,14-15,17,24H,5-9,13H2,1-4H3;1H

SMILES Code

6-Ethylamino-3-(3-Cyclopentyloxy-4-methoxybenzyl)-8-isopropyl-3H-purine hydrochloride

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 445.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Gale DD, Landells LJ, Spina D, Miller AJ, Smith K, Nichols T, Rotshteyn Y, Tonelli A, Lacouture P, Burch RM, Page CP, O'Connor BJ. Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol. 2002 Nov;54(5):478-84. doi: 10.1046/j.1365-2125.2002.01682.x. PMID: 12445026; PMCID: PMC1874476. Abdollahi M, Chan TS, Subrahmanyam V, O'Brien PJ. Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol Cell Biochem. 2003 Oct;252(1-2):205-11. doi: 10.1023/a:1025568714217. PMID: 14577594. Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. doi: 10.1038/bjp.2008.297. Epub 2008 Jul 28. PMID: 18660832; PMCID: PMC2567889.