Lactose, anhydrous | CAS# 63-42-3 | milk sugar

MedKoo Cat#: 591474 | Name: Lactose, anhydrous

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lactose (C12H22O11) is milk sugar. It is a disaccharide composed of one galactose and one glucose molecule. In the pharmaceutical industry, lactose is used to help form tablets because it has excellent compressibility properties.

Chemical Structure

Lactose, anhydrous

CAS# 63-42-3

Theoretical Analysis

MedKoo Cat#: 591474

Name: Lactose, anhydrous

CAS#: 63-42-3

Chemical Formula: C12H22O11

Exact Mass: 342.1162

Molecular Weight: 342.30

Elemental Analysis: C, 42.11; H, 6.48; O, 51.41

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

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Synonym

Lactose, anhydrous; Fast-flo; Lactose Galactinum

IUPAC/Chemical Name

D-Glucose, 4-O-beta-D-galactopyranosyl-

InChi Key

DKXNBNKWCZZMJT-JVCRWLNRSA-N

InChi Code

InChI=1S/C12H22O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-/m0/s1

SMILES Code

O=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O[C@H]1[C@@H]([C@H]([C@H]([C@@H](CO)O1)O)O)O)O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Lactose, a major sugar in the milk of most species, could regulate human’s intestinal microflora.

In vitro activity:

In the in vitro part of the study, a concentration-dependent inhibitory effect of lactose on in vitro C. perfringens α toxin activity was observed, whereas protein did not influence α toxin activity. Reference: J Dairy Sci. 2023 Jan;106(1):733-742. https://pubmed.ncbi.nlm.nih.gov/36333142/

In vivo activity:

Further, 13R054 G5P[7] and 12R046 G9P[23] infectivity was significantly reduced by β-lactose in MA104 cells and primary porcine enterocytes. These data suggest that lactose, the main natural sugar in milk, plays an important role in protecting piglets from enteric viral replication and diarrhea. Reference: Front Microbiol. 2022 Aug 17;13:989242. https://pubmed.ncbi.nlm.nih.gov/36060735/

Preparing Stock Solutions

The following data is based on the product molecular weight 342.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Derix J, Ducatelle R, Pardon B, Croes E, Nibbelink NG, Van Deurzen-Duineveld L, Van Immerseel F, Goossens E. The in vitro effect of lactose on Clostridium perfringens alpha toxin production and the implications of lactose consumption for in vivo anti-alpha toxin antibody production. J Dairy Sci. 2023 Jan;106(1):733-742. doi: 10.3168/jds.2022-22467. Epub 2022 Nov 1. PMID: 36333142. 2. Kobayashi K, Wakasa H, Han L, Koyama T, Tsugami Y, Nishimura T. Lactose on the basolateral side of mammary epithelial cells inhibits milk production concomitantly with signal transducer and activator of transcription 5 inactivation. Cell Tissue Res. 2022 Sep;389(3):501-515. doi: 10.1007/s00441-022-03651-8. Epub 2022 Jun 24. PMID: 35748981. 3. Ren X, Saleem W, Haes R, Xie J, Theuns S, Nauwynck HJ. Milk lactose protects against porcine group A rotavirus infection. Front Microbiol. 2022 Aug 17;13:989242. doi: 10.3389/fmicb.2022.989242. PMID: 36060735; PMCID: PMC9428151. 4. Escribano BM, Muñoz-Jurado A, Luque E, Conde C, Feijóo M, LaTorre M, Valdelvira ME, Buendía P, Giraldo AI, Caballero-Villarraso J, Santamaría A, Agüera E, Túnez I. Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis. CNS Neurol Disord Drug Targets. 2022;21(8):680-692. doi: 10.2174/1871527320666211207101113. PMID: 34875994.

In vitro protocol:

In vivo protocol:

1. Ren X, Saleem W, Haes R, Xie J, Theuns S, Nauwynck HJ. Milk lactose protects against porcine group A rotavirus infection. Front Microbiol. 2022 Aug 17;13:989242. doi: 10.3389/fmicb.2022.989242. PMID: 36060735; PMCID: PMC9428151. 2. Escribano BM, Muñoz-Jurado A, Luque E, Conde C, Feijóo M, LaTorre M, Valdelvira ME, Buendía P, Giraldo AI, Caballero-Villarraso J, Santamaría A, Agüera E, Túnez I. Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis. CNS Neurol Disord Drug Targets. 2022;21(8):680-692. doi: 10.2174/1871527320666211207101113. PMID: 34875994.

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