GC-072 is the etiological agent of melioidosis and a Gram-negative bacterium. GC-072 is a potent, 4-oxoquinolizine antibiotic with selective inhibitory activity against bacterial topoisomerases. GC-072 exhibits in vitro potency against susceptible and drug-resistant strains of B. pseudomallei, as well as other dangerous pathogens such as Burkholderia mallei, Bacillus anthracis, Yersinia pestis, and Francisella tularensis. When administered orally in mice models mimicking melioidosis infection, GC-072 showed dose-dependent survival benefits, suggesting its potential as a first-line oral treatment option for melioidosis.
MedKoo Cat#: 145117
Name: GC-072
CAS#: 1371629-36-5
Chemical Formula: C20H16F2N2O3
Exact Mass: 370.1129
Molecular Weight: 370.36
Elemental Analysis: C, 64.86; H, 4.35; F, 10.26; N, 7.56; O, 12.96
The following data is based on the product molecular weight 370.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
