Synonym
Salcomine; NSC 32965; NSC-32965; NSC32965
IUPAC/Chemical Name
Cobalt, ((2,2'-(1,2-ethanediylbis((nitrilo-kappaN)methylidyne))bis(phenolato-kappaO))(2-))-, (SP-4-2)-
InChi Key
NPAQSKHBTMUERN-OYJDLGDISA-L
InChi Code
InChI=1S/C16H16N2O2.Co/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;/h1-8,11-12,19-20H,9-10H2;/q;+2/p-2/b17-11+,18-12+;
SMILES Code
[N]12=CC3=CC=CC=C3O[Co]41OC5=CC=CC=C5C=[N]4CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Biological target:
Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.
In vitro activity:
Treatment of intermediate isochromene enol ether of 7,9-dimethoxy-3-methyl-1H-benzo[g]isochromene-5-ol with salcomine resulted in the formation of (3-formyl-4-hydroxy-6,8-dimethoxynaphthalene-2-yl)methyl acetate.
Reference: Org Biomol Chem. 2012 Oct 14;10(38):7809-19. https://pubmed.ncbi.nlm.nih.gov/22915091/
In vivo activity:
To be determined
Preparing Stock Solutions
The following data is based on the
product
molecular weight
325.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Pillay A, Rousseau AL, Fernandes MA, de Koning CB. The synthesis of the pyranonaphthoquinones dehydroherbarin and anhydrofusarubin using Wacker oxidation methodology as a key step and other unexpected oxidation reactions with ceric ammonium nitrate and salcomine. Org Biomol Chem. 2012 Oct 14;10(38):7809-19. doi: 10.1039/c2ob26126j. PMID: 22915091.
In vitro protocol:
1. Pillay A, Rousseau AL, Fernandes MA, de Koning CB. The synthesis of the pyranonaphthoquinones dehydroherbarin and anhydrofusarubin using Wacker oxidation methodology as a key step and other unexpected oxidation reactions with ceric ammonium nitrate and salcomine. Org Biomol Chem. 2012 Oct 14;10(38):7809-19. doi: 10.1039/c2ob26126j. PMID: 22915091.
In vivo protocol:
To be determined
1: Takizawa N, Kimura T, Watanabe T, Shibasaki M. Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis. Arch Virol. 2018 Jun;163(6):1607-1614. doi: 10.1007/s00705-018-3779-9. Epub 2018 Mar 1. PubMed PMID: 29497849.
2: Pillay A, Rousseau AL, Fernandes MA, de Koning CB. The synthesis of the pyranonaphthoquinones dehydroherbarin and anhydrofusarubin using Wacker oxidation methodology as a key step and other unexpected oxidation reactions with ceric ammonium nitrate and salcomine. Org Biomol Chem. 2012 Oct 14;10(38):7809-19. doi: 10.1039/c2ob26126j. PubMed PMID: 22915091.
3: Sakurai J, Oguchi T, Watanabe K, Abe H, Kanno S, Ishikawa M, Katoh T. Highly efficient total synthesis of the marine natural products (+)-avarone, (+)-avarol, (-)-neoavarone, (-)-neoavarol and (+)-aureol. Chemistry. 2008;14(3):829-37. PubMed PMID: 17992684.
4: Canevali C, Orlandi M, Zoia L, Scotti R, Tolppa EL, Sipila J, Agnoli F, Morazzoni F. Radicalization of lignocellulosic fibers, related structural and morphological changes. Biomacromolecules. 2005 May-Jun;6(3):1592-601. PubMed PMID: 15877382.
5: Yoshida M, Ono H, Mori Y, Chuda Y, Mori M. Oxygenation of bisphenol A to quinones by polyphenol oxidase in vegetables. J Agric Food Chem. 2002 Jul 17;50(15):4377-81. PubMed PMID: 12105973.
6: Yoshida M, Ono H, Mori Y, Chuda Y, Onishi K. Oxidation of bisphenol A and related compounds. Biosci Biotechnol Biochem. 2001 Jun;65(6):1444-6. PubMed PMID: 11471753.
7: Watanabe S, Konno K, Shigeta S, Yokota T. Inhibition of human cytomegalovirus proteinase by salcomine derivatives. Antivir Chem Chemother. 1998 May;9(3):269-74. PubMed PMID: 9875406.
8: Otsuji K, Sawada T, Satoh S, Kanda S, Matsumura H, Kondo S, Otsubo K. Preliminary experimental results of gas recycling subsystems except carbon dioxide concentration. Adv Space Res. 1987;7(4):69-72. PubMed PMID: 11537272.
9: GEISSMAN TA, SCHLATTER MJ, et al. The synthesis of some intermediates for use in the preparation of analogs of salicylaldehyde ethylenediimine cobalt (salcomine). J Org Chem. 1946 Nov;11(6):741-50. PubMed PMID: 20282498.
