SAHO2 | CAS#53199-56-7 | sulfone

MedKoo Cat#: 462114 | Name: SAHO2

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SAHO2 is a sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride and is a substrate for radical SAM enzymes.

Chemical Structure

SAHO2

CAS#53199-56-7

Theoretical Analysis

MedKoo Cat#: 462114

Name: SAHO2

CAS#: 53199-56-7

Chemical Formula: C14H20N6O7S

Exact Mass: 416.1114

Molecular Weight: 416.41

Elemental Analysis: C, 40.38; H, 4.84; N, 20.18; O, 26.89; S, 7.70

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 375.00	2 Weeks
5mg	USD 700.00	2 Weeks

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Related CAS #

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Synonym

SAHO2

IUPAC/Chemical Name

5′-[[(3S)-3-amino-3-carboxypropyl]sulfonyl]-5′-deoxy-adenosine

InChi Key

NUBHDZKYWTVIHP-WFMPWKQPSA-N

InChi Code

InChI=1S/C14H20N6O7S/c15-6(14(23)24)1-2-28(25,26)3-7-9(21)10(22)13(27-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1

SMILES Code

O[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@H]3CS(=O)(CC[C@H](N)C(O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO and PBS (pH 7.2)

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SAHO2 is a substrate for radical SAM enzymes. It is reductively cleaved to 5'-deoxyadenosine and 5'-thioadenosine sulfinic acid by the radical SAM enzymes NosL or NosN.

In vitro activity:

This study showed that NosL and NosN, are able to act on a sulfoxide SAHO and a sulfone SAHO2, both of which are structurally similar to SAM. NosL cleaves all three bonds connecting the sulfur center of SAHO, with a preference for S-C(5') bond cleavage. Similar S-C cleavage activity was also found for SHAO2, but no S-O cleavage was observed. NosN almost exclusively cleaves the S-C(5') bonds of SAHO and SAHO2 with much higher efficiencies. Reference: Biochemistry. 2019 Jan 8;58(1):36-39. https://pubmed.ncbi.nlm.nih.gov/30398855/

In vivo activity:

To be determined

	Solvent	mg/mL	mM
Solubility
	DMSO	30.0	72.04
	PBS (pH 7.2)	10.0	24.01

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 416.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Mandalapu D, Ji X, Zhang Q. Reductive Cleavage of Sulfoxide and Sulfone by Two Radical S-Adenosyl-l-methionine Enzymes. Biochemistry. 2019 Jan 8;58(1):36-39. doi: 10.1021/acs.biochem.8b00844. Epub 2018 Nov 12. PMID: 30398855.

In vitro protocol:

In vivo protocol:

To be determined

1: Mandalapu, D., Ji, X., and Zhang, Q. Reductive cleavage of sulfoxide and sulfone by two radical S-adenosyl-L-methionine enzymes. Biochemistry 58(1), 36-39 (2019).