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MedKoo Cat#: 145045 | Name: AKEX-0011

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AKEX0011 is a N-arylpyridone compound. Studies reveal its ability to ameliorate silica-induced lung damage, improve respiratory function, and reduce inflammatory and fibrotic factors, while also inhibiting apoptosis and regulating macrophage polarization. In vitro, AKEX0011 inhibited inflammatory cytokine secretion, suppressed macrophage apoptosis, and blocked the ASK1-p38 pathway, suggesting its efficacy in combating silica-induced pulmonary inflammation and fibrosis, making it a promising candidate for silicosis treatment.

Chemical Structure

AKEX-0011
AKEX-0011
CAS#1590403-33-0

Theoretical Analysis

MedKoo Cat#: 145045

Name: AKEX-0011

CAS#: 1590403-33-0

Chemical Formula: C18H14F3N5O2

Exact Mass: 389.1100

Molecular Weight: 389.34

Elemental Analysis: C, 55.53; H, 3.62; F, 14.64; N, 17.99; O, 8.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AKEX-0011; AKEX0011; AKEX 0011; GDC-3280; GDC3280; GDC 3280; AK-3287; AK3287; AK 3287
IUPAC/Chemical Name
1-methyl-7-(1-methyl-1H-pyrazol-4-yl)-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one
InChi Key
ZJBCIWSBSPECFD-UHFFFAOYSA-N
InChi Code
1S/C18H14F3N5O2/c1-24-10-22-15-16(24)14(11-7-23-25(2)8-11)9-26(17(15)27)12-3-5-13(6-4-12)28-18(19,20)21/h3-10H,1-2H3
SMILES Code
CN1C=C(C=N1)C2=CN(C(=O)C3=C2N(C)C=N3)C4=CC=C(OC(F)(F)F)C=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 389.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fan M, Xiao H, Song D, Zhu L, Zhang J, Zhang X, Wang J, Dai H, Wang C. A Novel N-Arylpyridone Compound Alleviates the Inflammatory and Fibrotic Reaction of Silicosis by Inhibiting the ASK1-p38 Pathway and Regulating Macrophage Polarization. Front Pharmacol. 2022 Mar 23;13:848435. doi: 10.3389/fphar.2022.848435. Erratum in: Front Pharmacol. 2023 Jan 18;13:1109002. Erratum in: Front Pharmacol. 2023 Jan 18;13:1108989. PMID: 35401236; PMCID: PMC8983992. 2: Fan M, Xiao H, Song D, Zhu L, Zhang J, Zhang X, Wang J, Dai H, Wang C. Erratum: Addendum: A novel N-Arylpyridone compound alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 pathway and regulating macrophage polarization. Front Pharmacol. 2023 Jan 18;13:1108989. doi: 10.3389/fphar.2022.1108989. Erratum for: Front Pharmacol. 2022 Mar 23;13:848435. PMID: 36744211; PMCID: PMC9890165. 3: Fan M, Xiao H, Song D, Zhu L, Zhang J, Zhang X, Wang J, Dai H, Wang C. Corrigendum: A novel N-arylpyridone compound alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 pathway and regulating macrophage polarization. Front Pharmacol. 2023 Jan 18;13:1109002. doi: 10.3389/fphar.2022.1109002. Erratum for: Front Pharmacol. 2022 Mar 23;13:848435. PMID: 36744209; PMCID: PMC9890144.