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MedKoo Cat#: 145034 | Name: Sericoside

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sericoside is a compound extracted from the bark of Terminalia sericea roots. Sericoside is proven to improve the set of gene expressions involved in cell cycle (+85% MKI67), cell proliferation (+250% IGF1), DNA repair (+56% OGG1), pluripotency transcription factors (+36% NANOG) and stem cells maintenance (+200% SOX2). The use of sericoside also resulted in a 17% increase in skin elasticity and a 10% reduction in skin roughness.

Chemical Structure

Sericoside
CAS#55306-04-2

Theoretical Analysis

MedKoo Cat#: 145034

Name: Sericoside

CAS#: 55306-04-2

Chemical Formula: C36H58O11

Exact Mass: 666.3979

Molecular Weight: 666.85

Elemental Analysis: C, 64.84; H, 8.77; O, 26.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
SERICOSIDE; SERICOSIDE [INCI]; SERICOSIDE VINYALS;
IUPAC/Chemical Name
(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (1S,4aR,6aS,6bR,8aR,9S,10R,11R,12aR,12bR,14bS)-1,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
InChi Key
CMZFNIMQBCBHEX-JRIAKSEUSA-N
InChi Code
1S/C36H58O11/c1-31(2)11-13-36(30(45)47-29-26(42)25(41)24(40)20(16-37)46-29)14-12-34(5)18(23(36)28(31)44)7-8-22-32(3)15-19(39)27(43)33(4,17-38)21(32)9-10-35(22,34)6/h7,19-29,37-44H,8-17H2,1-6H3/t19-,20-,21-,22-,23-,24-,25+,26-,27+,28+,29+,32+,33-,34-,35-,36+/m1/s1
SMILES Code
[H][C@]12CC=C3[C@]4([H])[C@H](O)C(C)(C)CC[C@@]4(CC[C@@]3(C)[C@]1(C)CC[C@H]5[C@@](C)(CO)[C@@H](O)[C@H](O)C[C@]25C)C(=O)O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 666.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Meunier M, Bracq M, Tiguemounine J, Maramaldi G, Scandolera A, Reynaud R. Skin Cellular Reprogramming as an Innovative Anti-Aging Strategy for Cosmetic Application: A Clinical Study of Sericoside. Front Biosci (Landmark Ed). 2023 Jun 12;28(6):112. doi: 10.31083/j.fbl2806112. PMID: 37395029. 2: Rode T, Frauen M, Müller BW, Düsing HJ, Schönrock U, Mundt C, Wenck H. Complex formation of sericoside with hydrophilic cyclodextrins: improvement of solubility and skin penetration in topical emulsion based formulations. Eur J Pharm Biopharm. 2003 Mar;55(2):191-8. doi: 10.1016/s0939-6411(02)00194-7. PMID: 12637096. 3: Mochizuki M, Hasegawa N. Acceleration of lipid degradation by sericoside of Terminalia sericea roots in Fully differentiated 3T3-L1 cells. Phytother Res. 2006 Nov;20(11):1020-1. doi: 10.1002/ptr.1999. PMID: 17009207. 4: Yang L, Zhang L, Du J, Shao L, Yu F, Li R, Zhong J. Two new oleanane triterpenoid saponins from Elsholtzia bodinieri. Nat Prod Res. 2021 Nov;35(21):3658-3666. doi: 10.1080/14786419.2020.1721489. Epub 2020 Feb 6. PMID: 32028800. 5: Mulaudzi N, Anokwuru CP, Tankeu SY, Combrinck S, Chen W, Vermaak I, Viljoen AM. Phytochemical Profiling and Quality Control of Terminalia sericea Burch. ex DC. Using HPTLC Metabolomics. Molecules. 2021 Jan 15;26(2):432. doi: 10.3390/molecules26020432. PMID: 33467662; PMCID: PMC7830210. 6: Anokwuru CP, Tankeu S, van Vuuren S, Viljoen A, Ramaite IDI, Taglialatela- Scafati O, Combrinck S. Unravelling the Antibacterial Activity of Terminalia sericea Root Bark through a Metabolomic Approach. Molecules. 2020 Aug 13;25(16):3683. doi: 10.3390/molecules25163683. PMID: 32823484; PMCID: PMC7464275. 7: Prinsloo G, Marokane CK, Street RA. Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research. J Ethnopharmacol. 2018 Jan 10;210:133-155. doi: 10.1016/j.jep.2017.08.005. Epub 2017 Aug 12. PMID: 28807850; PMCID: PMC7125770. 8: Mongalo NI, McGaw LJ, Segapelo TV, Finnie JF, Van Staden J. Ethnobotany, phytochemistry, toxicology and pharmacological properties of Terminalia sericea Burch. ex DC. (Combretaceae) - A review. J Ethnopharmacol. 2016 Dec 24;194:789-802. doi: 10.1016/j.jep.2016.10.072. Epub 2016 Oct 27. PMID: 27989875. 9: Ponou BK, Teponno RB, Ricciutelli M, Quassinti L, Bramucci M, Lupidi G, Barboni L, Tapondjou LA. Dimeric antioxidant and cytotoxic triterpenoid saponins from Terminalia ivorensis A. Chev. Phytochemistry. 2010 Dec;71(17-18):2108-15. doi: 10.1016/j.phytochem.2010.08.020. Epub 2010 Sep 16. PMID: 20850160. 10: Asres K, Bucar F, Knauder E, Yardley V, Kendrick H, Croft SL. In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle. Phytother Res. 2001 Nov;15(7):613-7. doi: 10.1002/ptr.897. PMID: 11746844. 11: Zhong J, Huang CG, Yu YJ, Li ZQ, Wang W, Huang XZ, Liu WX, Yuan Y, Jiang ZY. [Chemical constituents from Perovskia atriplicifolia]. Zhongguo Zhong Yao Za Zhi. 2015 Mar;40(6):1108-13. Chinese. PMID: 26226754. 12: Asres K, Bucar F, Edelsbrunner S, Kartnig T, Höger G, Thiel W. Investigations on antimycobacterial activity of some Ethiopian medicinal plants. Phytother Res. 2001 Jun;15(4):323-6. doi: 10.1002/ptr.724. PMID: 11406856. 13: Asres K, Bucar F. Anti-HIV activity against immunodeficiency virus type 1 (HIV-I) and type II (HIV-II) of compounds isolated from the stem bark of Combretum molle. Ethiop Med J. 2005 Jan;43(1):15-20. PMID: 16370525. 14: Hubert J, Nuzillard JM, Purson S, Hamzaoui M, Borie N, Reynaud R, Renault JH. Identification of natural metabolites in mixture: a pattern recognition strategy based on (13)C NMR. Anal Chem. 2014 Mar 18;86(6):2955-62. doi: 10.1021/ac403223f. Epub 2014 Mar 5. PMID: 24555703. 15: Dawé A, Talom B, Kapche GDWF, Siddiqui K, Yakai F, Talla E, Shaiq MA, Lubna I, Ngadjui BT. Termiglaucescin, a new polyhydroxy triterpene glucoside from Terminalia glaucescens with antioxidant and anti-inflammatory potential. Z Naturforsch C J Biosci. 2017 May 1;72(5-6):203-208. doi: 10.1515/znc-2016-0178. PMID: 27997356. 16: De Mesquita ML, De Paula JE, Espindola LS, Soares LAL, Da Silva TMG, Camara CA, Da Silva TMG. Protoflavanones from the Wood Stem of Salvertia convallariodora. Nat Prod Commun. 2017 Apr;12(4):515-518. PMID: 30520585. 17: Parkar H, Aiyegoro OA, Steenkamp P, Steenkamp V. Extracts of Terminalia sericea Enhance Cell Migratory Activity of Endothelial Hybrid and Fibroblast Cells In Vitro. Planta Med. 2017 Dec;83(18):1397-1404. doi: 10.1055/s-0043-113324. Epub 2017 Aug 2. PMID: 28770552. 18: Cao S, Brodie PJ, Callmander M, Randrianaivo R, Rakotobe E, Rasamison VE, Kingston DG. Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest. Phytochemistry. 2010 Jan;71(1):95-9. doi: 10.1016/j.phytochem.2009.09.027. Epub 2009 Oct 28. PMID: 19875137; PMCID: PMC2813959. 19: Tyagi R, Lala S, Verma AK, Nandy AK, Mahato SB, Maitra A, Basu MK. Targeted delivery of arjunglucoside I using surface hydrophilic and hydrophobic nanocarriers to combat experimental leishmaniasis. J Drug Target. 2005 Apr;13(3):161-71. doi: 10.1080/10611860500046732. PMID: 16036304. 20: Wang Y, Ye WC, Yin ZQ, Zhao SX. [Triterpene saponins from Adinandra nitida]. Yao Xue Xue Bao. 2008 May;43(5):504-8. Chinese. PMID: 18717338.

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NH4-6

NH4-6