MedKoo Cat#: 145033 | Name: Allantoin Panthenol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Allantoin Panthenol is a complex made of both allantoin and panthenol.

Chemical Structure

Allantoin Panthenol
Allantoin Panthenol
CAS#565227-55-6 (panthenol)

Theoretical Analysis

MedKoo Cat#: 145033

Name: Allantoin Panthenol

CAS#: 565227-55-6 (panthenol)

Chemical Formula: C13H25N5O7

Exact Mass: 363.1754

Molecular Weight: 363.37

Elemental Analysis: C, 42.97; H, 6.94; N, 19.27; O, 30.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
ALLANTOIN PANTHENOL; ALLANTOIN PANTHENOL [INCI]; ALPANTHA;
IUPAC/Chemical Name
(R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide compound with 1-(2,5-dioxoimidazolidin-4-yl)urea (1:1)
InChi Key
DMVGDAWWCIUOJI-FJXQXJEOSA-N
InChi Code
1S/C9H19NO4.C4H6N4O3/c1-9(2,6-12)7(13)8(14)10-4-3-5-11;5-3(10)6-1-2(9)8-4(11)7-1/h7,11-13H,3-6H2,1-2H3,(H,10,14);1H,(H3,5,6,10)(H2,7,8,9,11)/t7-;/m0./s1
SMILES Code
NC(=O)NC1NC(=O)NC1=O.CC(C)(CO)[C@@H](O)C(=O)NCCCO
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 363.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Final report of the safety assessment of allantoin and its related complexes. Int J Toxicol. 2010 May;29(3 Suppl):84S-97S. doi: 10.1177/1091581810362805. PMID: 20448269. 2: Tan C, Peng K, Lim T, Liu J, Ye Y, Lim L, Gao P, Oblong JE, Lam T. The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE2 synthesis by keratinocytes. Int J Cosmet Sci. 2024 Mar 3. doi: 10.1111/ics.12951. Epub ahead of print. PMID: 38433250. 3: Ferreira MS, Sousa Lobo JM, Almeida IF. Sensitive skin: Active ingredients on the spotlight. Int J Cosmet Sci. 2022 Feb;44(1):56-73. doi: 10.1111/ics.12754. Epub 2021 Dec 14. PMID: 34813665. 4: Ferreira EB, Vasques CI, Gadia R, Chan RJ, Guerra EN, Mezzomo LA, De Luca Canto G, Dos Reis PE. Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review. Support Care Cancer. 2017 Mar;25(3):1001-1011. doi: 10.1007/s00520-016-3521-7. Epub 2016 Dec 12. PMID: 27957620. 5: Sáez-Alcaide LM, Molinero-Mourelle P, González-Serrano J, Rubio-Alonso L, Bornstein MM, López-Quiles J. Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2020 Sep 1;25(5):e644-e651. doi: 10.4317/medoral.23661. PMID: 32683390; PMCID: PMC7473436. 6: Park SJ, Han HS. Effects of a facial mask containing zinc oxide-based cream on improving post-laser skin care. J Cosmet Dermatol. 2023 Nov;22(11):3181-3184. doi: 10.1111/jocd.15808. Epub 2023 May 12. PMID: 37171369. 7: Lopez-Lopez J, Jan-Pallí E, lez-Navarro BG, Jané-Salas E, Estrugo-Devesa A, Milani M. Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. Curr Med Res Opin. 2015 Dec;31(12):2179-83. doi: 10.1185/03007995.2015.1108909. Epub 2015 Nov 4. Erratum in: Curr Med Res Opin. 2016;32(2):395. Lope-Lopez, Jose [corrected to Lopez-Lopez, Jose]; González-Navarro, Beatriz [corrected to lez- Navarro, Beatriz Gonzá]. PMID: 26471464. 8: Madrazo-Jiménez M, Rodríguez-Caballero Á, Serrera-Figallo MÁ, Garrido-Serrano R, Gutiérrez-Corrales A, Gutiérrez-Pérez JL, Torres-Lagares D. The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction. Med Oral Patol Oral Cir Bucal. 2016 Nov 1;21(6):e696-e702. doi: 10.4317/medoral.21281. PMID: 27475700; PMCID: PMC5116111. 9: Heine H. Transkutane Heparintherapie. Experimentell histologische Untersuchungen mit der Wirkkombination Heparin--Allantoin--D-Panthenol [Transcutaneous heparin therapy. Experimental histological studies with the effective combination heparin--allantoin--D panthenol]. Med Welt. 1983 May 20;34(20):602-4. German. PMID: 6877066. 10: Han HS, Park JW, Shin SH, Yoo KH, Sohn YS, Kim BJ. Single-center, assessor- blind study to evaluate the efficacy and safety of DA-5520 topical gel in patients with acne scars: A pilot study. J Cosmet Dermatol. 2022 Sep;21(9):3888-3895. doi: 10.1111/jocd.14693. Epub 2022 Jan 4. PMID: 34982507. 11: Lee DW, Ku SK, Cho HJ, Kim JH, Hiep TT, Han SD, Kim BG, Kang MK, Do ES, Jun JH, Jang SW, Son MW, Sohn YT, Choi HG, Yong CS, Kim JO. Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: histopathological aspects. Arch Pharm Res. 2012 Nov;35(11):1999-2006. doi: 10.1007/s12272-012-1117-4. Epub 2012 Dec 4. PMID: 23212642. 12: Forero-Doria O, Polo E, Marican A, Guzmán L, Venegas B, Vijayakumar S, Wehinger S, Guerrero M, Gallego J, Durán-Lara EF. Supramolecular hydrogels based on cellulose for sustained release of therapeutic substances with antimicrobial and wound healing properties. Carbohydr Polym. 2020 Aug 15;242:116383. doi: 10.1016/j.carbpol.2020.116383. Epub 2020 May 23. PMID: 32564841. 13: Ávila-Salas F, Marican A, Pinochet S, Carreño G, Valdés O, Venegas B, Donoso W, Cabrera-Barjas G, Vijayakumar S, Durán-Lara EF. Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties. Pharmaceutics. 2019 Sep 2;11(9):447. doi: 10.3390/pharmaceutics11090447. PMID: 31480682; PMCID: PMC6781310. 14: Tauschel HD, Bonacina F, Galetti F. Untersuchungen zur perkutanen Wirksamkeit von Heparin-Allantoin-Dexpanthenol-Kombinationen in spezieller Salbengrundlage. Thrombolytische Wirkung am Hasenohr [The percutaneous action of a heparin-allantoin-dexpanthenol combination in a specific ointment base. Thrombolytic action on the rabbit ear]. Arzneimittelforschung. 1984;34(12):1768-72. German. PMID: 6543312. 15: Harnoss JC, Elrub QMA, Jung JO, Koburger T, Assadian O, Dissemond J, Baguhl R, Papke R, Kramer A; Supported by the Working Group Antiseptics of the International Society of Chemotherapy for Infection and Cancer (ISC). Irritative potency of selected wound antiseptics in the hen's egg test on chorioallantoic membrane to predict their compatibility to wounds. Wound Repair Regen. 2019 Mar;27(2):183-189. doi: 10.1111/wrr.12689. Epub 2018 Dec 5. PMID: 30520197. 16: Tauschel HD, Rudolph C. Untersuchungen zur perkutanen Wirksamkeit einer Heparin-Allantoin-Dexpanthenol-Kombination in spezieller Salbengrundlage. Antiinflammatorische Wirkung auf UV-Erytheme am Meerschweinchen [Investigations on the percutaneous activity of a combination of heparin, allantoin and dexpanthenol in a specific ointment base, Antiinflammatory effect on UV-erythema in the guinea pig]. Arzneimittelforschung. 1982;32(9):1096-100. German. PMID: 6890833. 17: Magaz VR, Llovera BF, Martí M, Garre A. Clinical Impact and Cosmetic Acceptability of Chlorhexidine-enriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study. J Contemp Dent Pract. 2018 Nov 1;19(11):1295-1300. PMID: 30602630. 18: Rudolph C, Tauschel HD. Untersuchungen zur perkutanen Wirksamkeit einer Heparin-Allantoin-Dexpanthenol-Kombination in spezieller Salbengrundlage. Antiallergische/antiinflammatorische Wirkung im PCA-Test bei der Ratte [The percutaneous effect of a heparin-allantoin-dexpanthenol combination in a specific ointment base. Anti-allergic, anti-inflammatory effect in the PCA test in the rat]. Arzneimittelforschung. 1984;34(12):1766-8. German. PMID: 6543311. 19: Waterloh E, Groth KH. Zur Objektivierung der Wirksamkeit eines Externums bei Sprunggelenksverletzungen mit Hilfe einer volumetrischen Methode [Objectification of the efficacy of an ointment for joint injuries using a volumetric method]. Arzneimittelforschung. 1983;33(5):792-5. German. PMID: 6347211.