GB1908 is a selective and Orally Available Galectin‑1 Inhibitor. GB1908 is a Potential Treatment for Lung Cancer. In vitro GB1908 inhibited galectin-1-induced apoptosis in Jurkat cells (IC50 = 850 nM). Pharmacokinetic experiments in mice revealed that a dose of 30 mg/kg b.i.d. results in free levels of GB1908 in plasma over galectin-1 Kd for 24 h. GB1908 dosed with this regimen reduced the growth of primary lung tumor LL/2 in a syngeneic mouse model.
MedKoo Cat#: 127080
Name: GB1908
CAS#: N/A
Chemical Formula: C18H18Cl2N4O5S2
Exact Mass: 504.0096
Molecular Weight: 505.39
Elemental Analysis: C, 42.78; H, 3.59; Cl, 14.03; N, 11.09; O, 15.83; S, 12.69
The following data is based on the product molecular weight 505.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
