Synonym
L-97-1; L 97-1; L97-1;
IUPAC/Chemical Name
3-(4-aminophenethyl)-8-benzyl-7-(2-(ethyl(2-hydroxyethyl)amino)ethyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione
InChi Key
QVEHDKFBFDUCEZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H38N6O3/c1-3-15-35-28(37)26-27(34(29(35)38)16-14-22-10-12-24(30)13-11-22)31-25(21-23-8-6-5-7-9-23)33(26)18-17-32(4-2)19-20-36/h5-13,36H,3-4,14-21,30H2,1-2H3
SMILES Code
O=C(N1CCC)N(CCC2=CC=C(N)C=C2)C3=C(N(CCN(CC)CCO)C(CC4=CC=CC=C4)=N3)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
518.66
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wilson CN, Vance CO, Lechner MG, Matuschak GM, Lechner AJ. Adenosine A1 receptor antagonist, L-97-1, improves survival and protects the kidney in a rat model of cecal ligation and puncture induced sepsis. Eur J Pharmacol. 2014 Oct 5;740:346-52. doi: 10.1016/j.ejphar.2014.07.012. Epub 2014 Jul 18. PubMed PMID: 25041842; PubMed Central PMCID: PMC4147868.
2: Cullen L, Parsonage WA, Greenslade J, Lamanna A, Hammett CJ, Than M, Tate J, Kalinowski L, Ungerer JP, Chu K, Brown A. Delta troponin for the early diagnosis of AMI in emergency patients with chest pain. Int J Cardiol. 2013 Oct 3;168(3):2602-8. doi: 10.1016/j.ijcard.2013.03.044. Epub 2013 Apr 10. PubMed PMID: 23582689.
3: Wilson CN, Vance CO, Doyle TM, Brink DS, Matuschak GM, Lechner AJ. A novel post-exposure medical countermeasure L-97-1 improves survival and acute lung injury following intratracheal infection with Yersinia pestis. Innate Immun. 2012 Jun;18(3):373-89. doi: 10.1177/1753425911411595. Epub 2011 Aug 23. PubMed PMID: 21862597; PubMed Central PMCID: PMC3362682.
4: Rehman S, Lloyd-Jones DM, Martinez-Rumayor A, Januzzi JL. Inflammatory markers, amino-terminal pro-brain natriuretic peptide, and mortality risk in dyspneic patients. Am J Clin Pathol. 2008 Aug;130(2):305-11. doi: 10.1309/L7BP57F7UF7YNYKX. PubMed PMID: 18628102.
5: Nadeem A, Obiefuna PC, Wilson CN, Mustafa SJ. Adenosine A1 receptor antagonist versus montelukast on airway reactivity and inflammation. Eur J Pharmacol. 2006 Dec 3;551(1-3):116-24. Epub 2006 Sep 8. PubMed PMID: 17027749; PubMed Central PMCID: PMC1766326.
6: Obiefuna PC, Batra VK, Nadeem A, Borron P, Wilson CN, Mustafa SJ. A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}- 1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. J Pharmacol Exp Ther. 2005 Oct;315(1):329-36. Epub 2005 Jul 14. PubMed PMID: 16020631.
7: Goud C, DiPiero A, Lockette WE, Webb RC, Charpie JR. Cyclic GMP-independent mechanisms of nitric oxide-induced vasodilation. Gen Pharmacol. 1999 Jan;32(1):51-5. PubMed PMID: 9888254.
