Hispolon | phenol | I. hispidus | CAS#173933-40-9

MedKoo Cat#: 127051 | Name: Hispolon

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hispolon is a phenol originally isolated from I. hispidus that has diverse biological activities.

Chemical Structure

Hispolon

CAS#173933-40-9

Theoretical Analysis

MedKoo Cat#: 127051

Name: Hispolon

CAS#: 173933-40-9

Chemical Formula: C12H12O4

Exact Mass: 220.0736

Molecular Weight: 220.22

Elemental Analysis: C, 65.45; H, 5.49; O, 29.06

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
200mg	USD 1,650.00	2 Weeks
500mg	USD 3,250.00	2 Weeks
1g	USD 4,950.00	2 Weeks
2g	USD 7,950.00	2 Weeks

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Related CAS #

No Data

Synonym

hispolon; 173933-40-9; HISPOLON(P)

IUPAC/Chemical Name

(3Z,5E)-6-(3,4-dihydroxyphenyl)-4-hydroxyhexa-3,5-dien-2-one

InChi Key

QDVIEIMMEUCFMW-QXYPORFMSA-N

InChi Code

InChI=1S/C12H12O4/c1-8(13)6-10(14)4-2-9-3-5-11(15)12(16)7-9/h2-7,14-16H,1H3/b4-2+,10-6-

SMILES Code

O=C(C)/C=C(O)/C=C/C1=CC(O)=C(C=C1)O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Biological target:

In vitro activity:

Twenty overlapping targets were screened by matching the 107 targets of Hispolon to the 2,013 targets of TNBC DEG. Seven core targets of Hispolon against TNBC were initially identified, including EGFR, IGFBP3, MMP9, MMP2, MMP1, PLAU, and KIT. In this study, the polygenic pharmacological mechanism of action of Hispolon against TNBC was explored through network pharmacology and in vitro experiments. References: Li J, Bao J, Wu L, Sun T, Zhao J, Luo F, Tao F, Liu W. A Bioinformatic Strategy for Investigating the Mechanism of Hispolon in the Treatment of Triple-Negative Breast Cancer Combined with In vitro Experiments. Curr Cancer Drug Targets. 2024 Aug 6. doi: 10.2174/0115680096313623240801070716. Epub ahead of print. PMID: 39108110.

In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 220.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang CY, Deng JS, Huang WC, Jiang WP, Huang GJ. Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Nutrients. 2020 Jun 10;12(6):1742. doi: 10.3390/nu12061742. PMID: 32532087; PMCID: PMC7352175. 2: Sarfraz A, Rasul A, Sarfraz I, Shah MA, Hussain G, Shafiq N, Masood M, Adem Ş, Sarker SD, Li X. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environ Res. 2020 Nov;190:110017. doi: 10.1016/j.envres.2020.110017. Epub 2020 Aug 6. PMID: 32768475; PMCID: PMC7406431. 3: Islam MT, Ali ES, Khan IN, Shaw S, Uddin SJ, Rouf R, Dev S, Saravi SSS, Das N, Tripathi S, Yele SU, Das AK, Shilpi JA, Mishra SK, Mubarak MS. Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon. Anticancer Agents Med Chem. 2020;20(14):1636-1647. doi: 10.2174/1871520620666200619164947. PMID: 32560616. 4: Thimmuri D, P A S, N P S, Khan A, Gawali B, Rajdev B, Adhikari C, V R, Sharma P, Naidu V. Hispolon inhibits RANKL induced osteoclast differentiation in vitro. Immunol Lett. 2021 Mar;231:35-42. doi: 10.1016/j.imlet.2021.01.003. Epub 2021 Jan 8. PMID: 33428992. 5: Yang WE, Chen YT, Su CW, Chen MK, Yeh CM, Chen YL, Tsai MY, Yang SF, Lin CW. Hispolon induces apoptosis in oral squamous cell carcinoma cells through JNK/HO-1 pathway activation. J Cell Mol Med. 2023 May;27(9):1250-1260. doi: 10.1111/jcmm.17729. Epub 2023 Mar 27. PMID: 36967712; PMCID: PMC10148051. 6: Hsin MC, Hsieh YH, Wang PH, Ko JL, Hsin IL, Yang SF. Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells. Cell Death Dis. 2017 Oct 5;8(10):e3089. doi: 10.1038/cddis.2017.459. PMID: 28981104; PMCID: PMC5680581. 7: Peng S, Hou Y, Chen Z. Hispolon alleviates oxidative damage by stimulating the Nrf2 signaling pathway in PC12 cells. Arch Biochem Biophys. 2022 Sep 30;727:109303. doi: 10.1016/j.abb.2022.109303. Epub 2022 May 31. PMID: 35660410. 8: Aanniz T, Zeouk I, Elouafy Y, Touhtouh J, Hassani R, Hammani K, Benali T, El- Shazly M, Khalid A, Abdalla AN, Aboulaghras S, Goh KW, Ming LC, Razi P, Bakrim S, Bouyahya A. Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms. Biomed Pharmacother. 2024 Aug;177:117072. doi: 10.1016/j.biopha.2024.117072. Epub 2024 Jul 10. PMID: 38991301. 9: Arcella A, Oliva MA, Sanchez M, Staffieri S, Esposito V, Giangaspero F, Cantore G. Effects of hispolon on glioblastoma cell growth. Environ Toxicol. 2017 Sep;32(9):2113-2123. doi: 10.1002/tox.22419. Epub 2017 Jun 15. PMID: 28618133. 10: Lee EK, Koh EM, Kim YN, Song J, Song CH, Jung KJ. Immunomodulatory Effect of Hispolon on LPS-Induced RAW264.7 Cells and Mitogen/Alloantigen-Stimulated Spleen Lymphocytes of Mice. Pharmaceutics. 2022 Jul 6;14(7):1423. doi: 10.3390/pharmaceutics14071423. PMID: 35890318; PMCID: PMC9322787. 11: Poudel I, Annaji M, Wibowo FS, Arnold RD, Fasina O, Via B, Rangari V, Peresin MS, Smith F, Dhanasekaran M, Tiwari AK, Babu RJ. Hispolon Cyclodextrin Complexes and Their Inclusion in Liposomes for Enhanced Delivery in Melanoma Cell Lines. Int J Mol Sci. 2022 Nov 21;23(22):14487. doi: 10.3390/ijms232214487. PMID: 36430965; PMCID: PMC9695989. 12: Al Saqr A, Majrashi M, Alrbyawi H, Govindarajulu M, Fujihashi A, Gottumukkala S, Poudel I, Arnold RD, Babu RJ, Dhanasekaran M. Elucidating the anti-melanoma effect and mechanisms of Hispolon. Life Sci. 2020 Sep 1;256:117702. doi: 10.1016/j.lfs.2020.117702. Epub 2020 May 6. PMID: 32387411. 13: Zhao Z, Sun YS, Chen W, Lv LX, Li YQ. Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway. Oncol Rep. 2016 Feb;35(2):896-904. doi: 10.3892/or.2015.4445. Epub 2015 Nov 25. Erratum in: Oncol Rep. 2024 Oct;52(4):134. doi: 10.3892/or.2024.8793. PMID: 26718128. 14: Wu Q, Kang Y, Zhang H, Wang H, Liu Y, Wang J. The anticancer effects of hispolon on lung cancer cells. Biochem Biophys Res Commun. 2014 Oct 24;453(3):385-91. doi: 10.1016/j.bbrc.2014.09.098. Epub 2014 Sep 28. PMID: 25268766. 15: Wang J, Hu F, Luo Y, Luo H, Huang N, Cheng F, Deng Z, Deng W, Zou K. Estrogenic and anti-estrogenic activities of hispolon from Phellinus lonicerinus (Bond.) Bond. et sing. Fitoterapia. 2014 Jun;95:93-101. doi: 10.1016/j.fitote.2014.03.007. Epub 2014 Mar 15. PMID: 24637110. 16: Jang EH, Jang SY, Cho IH, Hong D, Jung B, Park MJ, Kim JH. Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha. Biochem Biophys Res Commun. 2015 Aug 7;463(4):917-22. doi: 10.1016/j.bbrc.2015.06.035. Epub 2015 Jun 6. PMID: 26056942. 17: Chen YC, Chang HY, Deng JS, Chen JJ, Huang SS, Lin IH, Kuo WL, Chao W, Huang GJ. Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells. Am J Chin Med. 2013;41(6):1439-57. doi: 10.1142/S0192415X13500961. PMID: 24228611. 18: Liao KF, Chiu TL, Chang SF, Wang MJ, Chiu SC. Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo. Molecules. 2021 Jul 26;26(15):4497. doi: 10.3390/molecules26154497. PMID: 34361649; PMCID: PMC8348445. 19: Kim JH, Kim YC, Park B. Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors. Oncol Rep. 2016 Feb;35(2):1020-6. doi: 10.3892/or.2015.4440. Epub 2015 Nov 20. PMID: 26718925. 20: Huang GJ, Deng JS, Huang SS, Hu ML. Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation. J Agric Food Chem. 2011 Jul 13;59(13):7104-13. doi: 10.1021/jf201289e. Epub 2011 Jun 10. PMID: 21630638.