CTP-347 is a deuterated version of paroxetine and a potentially best-in-class non-hormonal agent for the management of hot flashes. CTP-347 demonstrated similar selectivity for the serotonin receptor, as well as similar neurotransmitter uptake inhibition in an in vitro rat synaptosome model, as unmodified paroxetine. However, human liver microsomes cleared CTP-347 faster than paroxetine as a result of decreased inactivation of CYP2D6. In phase 1 studies, CTP-347 was metabolized more rapidly in humans and exhibited a lower pharmacokinetic accumulation index than paroxetine. (last updated: 5/10/2016).
MedKoo Cat#: 526623
Name: CTP-347
CAS#: 923932-43-8
Chemical Formula: C19H18D2FNO3
Exact Mass: 331.1553
Molecular Weight: 331.38
Elemental Analysis: C, 68.87; H, 6.69; F, 5.73; N, 4.23; O, 14.48
The following data is based on the product molecular weight 331.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
