NSC 25433 is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It inhibits Streptomyces chitin synthase 1 (IC50 = 14 µg/ml) but not C. albicans chitin synthase 2 when used at concentrations up to 280 µg/ml. NSC 25433 is active against the fungus C. neoformans and the plant pathogenic fungus R. solani (MIC = 50 µg/ml for both). It enhances insulin-induced adipocyte differentiation in 3T3-L1 and C3H/10T1/2 cells when used at concentrations of 30 and 100 µM.
MedKoo Cat#: 465291
Name: NSC 25433
CAS#: 5467-84-5
Chemical Formula: C17H20N2O
Exact Mass: 268.1576
Molecular Weight: 268.36
Elemental Analysis: C, 76.09; H, 7.51; N, 10.44; O, 5.96
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 111.79 | |
| DMSO | 30.0 | 111.79 | |
| DMSO:PBS (pH 7.2) (1:4) | 0.2 | 0.75 | |
| Ethanol | 1.0 | 3.73 |
The following data is based on the product molecular weight 268.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
