LC-MI-3 is a Potent and Orally Bioavailable IRAK4 degrader for the Treatment of Inflammatory Diseases. LC-MI-3 effectively degraded cellular IRAK4, with a half-maximal degradation concentration of 47.3 nM. LC-MI-3 effectively inhibited the activation of downstream nuclear factor-κB signaling and exerted more potent pharmacological effects than traditional kinase inhibitors. Furthermore, LC-MI-3 exerted significant therapeutic effects in lipopolysaccharide- and Escherichia coli-induced acute and chronic inflammatory skin models compared with kinase inhibitors in vivo.
MedKoo Cat#: 126934
Name: LC-MI-3
CAS#: N/A
Chemical Formula: C39H36N8O8
Exact Mass: 744.2656
Molecular Weight: 744.77
Elemental Analysis: C, 62.90; H, 4.87; N, 15.05; O, 17.19
The following data is based on the product molecular weight 744.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
