MedKoo Cat#: 564135 | Name: LCB03-0110

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LCB03-0110 is a potent angiogenesis inhibitor. LCB03-0110 inhibits VEGFR-2 and JAK/STAT3 signalling in primary cultured human endothelial cells and cancer cells.

Chemical Structure

LCB03-0110
LCB03-0110
CAS#1228102-01-9

Theoretical Analysis

MedKoo Cat#: 564135

Name: LCB03-0110

CAS#: 1228102-01-9

Chemical Formula: C24H23N3O2S

Exact Mass: 417.1511

Molecular Weight: 417.53

Elemental Analysis: C, 69.04; H, 5.55; N, 10.06; O, 7.66; S, 7.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LCB03-0110; LCB030110; LCB03 0110
IUPAC/Chemical Name
3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol
InChi Key
ZCWXCBKGPJOAFQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23N3O2S/c28-20-6-2-5-19(14-20)26-21-7-8-25-22-15-23(30-24(21)22)18-4-1-3-17(13-18)16-27-9-11-29-12-10-27/h1-8,13-15,28H,9-12,16H2,(H,25,26)
SMILES Code
OC1=CC=CC(NC2=C3C(C=C(C4=CC=CC(CN5CCOCC5)=C4)S3)=NC=C2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 417.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim BH, Lee Y, Yoo H, Cui M, Lee S, Kim SY, Cho JU, Lee H, Yang BS, Kwon YG, Choi S, Kim TY. Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling. Exp Dermatol. 2015 Jul;24(7):503-9. doi: 10.1111/exd.12698. Epub 2015 Apr 27. PubMed PMID: 25808463.