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MedKoo Cat#: 599056 | Name: LK-614

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LK-614 is a newly developed iron chelator.

Chemical Structure

LK-614
CAS#82461-57-2

Theoretical Analysis

MedKoo Cat#: 599056

Name: LK-614

CAS#: 82461-57-2

Chemical Formula: C10H13NO4

Exact Mass: 211.0845

Molecular Weight: 211.21

Elemental Analysis: C, 56.87; H, 6.20; N, 6.63; O, 30.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LK-614; LK 614; LK614
IUPAC/Chemical Name
N-hydroxy-3,4-dimethoxy-N-methylbenzamide
InChi Key
CFAMAWCPWJCAFR-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H13NO4/c1-11(13)10(12)7-4-5-8(14-2)9(6-7)15-3/h4-6,13H,1-3H3
SMILES Code
O=C(N(O)C)C1=CC=C(OC)C(OC)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 211.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Koch A, Loganathan S, Radovits T, Sack FU, Karck M, Szabó GB. Deferoxamine, the newly developed iron chelator LK-614 and N-alpha-acetyl-histidine in myocardial protection. Interact Cardiovasc Thorac Surg. 2010 Feb;10(2):181-4. doi: 10.1510/icvts.2009.213280. Epub 2009 Nov 13. PubMed PMID: 19914924. 2: Wu S, Wohlschlaeger J, de Groot H, Rauen U. Evaluation of a modified HTK solution containing the new iron chelator LK 614 in an isolated rat liver perfusion model. J Invest Surg. 2009 Sep-Oct;22(5):340-7. PubMed PMID: 19842888. 3: Veres G, Radovits T, Merkely B, Karck M, Szabó G. Custodiol-N, the novel cardioplegic solution reduces ischemia/reperfusion injury after cardiopulmonary bypass. J Cardiothorac Surg. 2015 Feb 28;10:27. doi: 10.1186/s13019-015-0226-9. PubMed PMID: 25890005; PubMed Central PMCID: PMC4350983. 4: Stegemann J, Hirner A, Rauen U, Minor T. Use of a new modified HTK solution for machine preservation of marginal liver grafts. J Surg Res. 2010 May 1;160(1):155-62. doi: 10.1016/j.jss.2008.10.021. Epub 2008 Dec 25. PubMed PMID: 19541327. 5: Pless G, Sauer IM, Rauen U. Improvement of the cold storage of isolated human hepatocytes. Cell Transplant. 2012;21(1):23-37. doi: 10.3727/096368911X580509. Epub 2011 Jun 7. PubMed PMID: 21669032. 6: Pizanis N, Gillner S, Kamler M, de Groot H, Jakob H, Rauen U. Cold-induced injury to lung epithelial cells can be inhibited by iron chelators - implications for lung preservation. Eur J Cardiothorac Surg. 2011 Oct;40(4):948-55. doi: 10.1016/j.ejcts.2011.01.052. Epub 2011 Mar 12. PubMed PMID: 21398140. 7: Zatschler B, Dieterich P, Müller B, Kasper M, Rauen U, Deussen A. Improved vessel preservation after 4 days of cold storage: experimental study in rat arteries. J Vasc Surg. 2009 Aug;50(2):397-406. doi: 10.1016/j.jvs.2009.04.064. PubMed PMID: 19631875. 8: Radovits T, Lin LN, Zotkina J, Koch A, Rauen U, Köhler G, Karck M, Szabó G. Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-alpha-acetyl-L-histidine. J Heart Lung Transplant. 2008 Feb;27(2):208-16. doi: 10.1016/j.healun.2007.11.002. PubMed PMID: 18267229. 9: Wille T, de Groot H, Rauen U. Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments. J Vasc Surg. 2008 Feb;47(2):422-31. doi: 10.1016/j.jvs.2007.09.048. PubMed PMID: 18164170. 10: Rauen U, Klempt S, de Groot H. Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators. Cell Mol Life Sci. 2007 Jan;64(2):192-205. PubMed PMID: 17180300. 11: Fernando SD, Gunawardena DM, Bandara MR, De Silva D, Carter R, Mendis KN, Wickremasinghe AR. The impact of repeated malaria attacks on the school performance of children. Am J Trop Med Hyg. 2003 Dec;69(6):582-8. PubMed PMID: 14740872.

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