SC0191 | CAS#2510782-14-4 | Wee1 inhibitor

MedKoo Cat#: 465414 | Name: SC0191

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SC0191 is a Wee1 inhibitor. SC0191 displayed potent kinase inhibiting activity for Wee1 with IC50 22.3 nM. SC0191 significantly inhibited tumor cell proliferation in TP53 mutant NCI-H446 cells with IC50 231.1 nM and BxPC-3 cells with IC50 223.8 nM. Moreover, SC0191 oral administration showed significant antitumor efficacy which was better than AZD1775, in the NCI-H446 and BxPC-3 CDX mouse models, respectively.

Chemical Structure

SC0191

CAS#2510782-14-4

Theoretical Analysis

MedKoo Cat#: 465414

Name: SC0191

CAS#: 2510782-14-4

Chemical Formula: C28H32N8O2

Exact Mass: 512.2648

Molecular Weight: 512.62

Elemental Analysis: C, 65.61; H, 6.29; N, 21.86; O, 6.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SC0191; SC 0191; SC-0191;

IUPAC/Chemical Name

(R,Z)-12-hydroxy-12-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7,10,11,12-tetrahydro-5H-13,17-(azeno)pyrimido[4',5':3,4]pyrazolo[1,2-a][1,2]diazacyclotridecin-5-one

InChi Key

KSZKLDQYICQTLL-WHQCRVIKSA-N

InChi Code

InChI=1S/C28H32N8O2/c1-28(38)13-4-3-5-14-35-26(37)22-19-29-27(32-25(22)36(35)24-8-6-7-23(28)31-24)30-20-9-11-21(12-10-20)34-17-15-33(2)16-18-34/h3,5-12,19,38H,4,13-18H2,1-2H3,(H,29,30,32)/b5-3-/t28-/m1/s1

SMILES Code

CN1CCN(C2=CC=C(NC3=NC=C4C(N5N(C/C=C\CC[C@](O)(C)C6=NC5=CC=C6)C4=O)=N3)C=C2)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

TP53 mutation is common in cancer cells, especially in small cell lung cancer (SCLC) and pancreatic cancer (PC). The G1 checkpoint function is lost in these cancer cells, which more rely on G2 checkpoint to repair damaged DNA. Wee1 is a serine/threonine kinase, which phosphorylates the Tyr15 locus of CDC2, inhibits the activity of CDC2, and stays in the G2 phase. Wee1 inhibition can promote the cells with DNA damage into the M phase, thus driving the TP53 mutant cancer cells to apoptosis.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 512.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.