MedKoo Cat#: 598810 | Name: Meclofenoxate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Meclofenoxate is a cholinergic nootropic used as a dietary supplement and drug in the treatment of symptoms of senile dementia and Alzheimer's disease. It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

Chemical Structure

Meclofenoxate
Meclofenoxate
CAS#51-68-3

Theoretical Analysis

MedKoo Cat#: 598810

Name: Meclofenoxate

CAS#: 51-68-3

Chemical Formula: C12H15ClNO3

Exact Mass: 256.0746

Molecular Weight: 256.70

Elemental Analysis: C, 56.15; H, 5.89; Cl, 13.81; N, 5.46; O, 18.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Meclofenoxate; EN 1627; NSC 169411; NSC-169411; NSC169411; Centrexin; Meclofenossato; Deanolestere;
IUPAC/Chemical Name
2-(4-chlorophenoxy)-2-(dimethylamino)butanoate
InChi Key
FFEHPEVNVMKXFG-UHFFFAOYSA-M
InChi Code
InChI=1S/C12H16ClNO3/c1-4-12(11(15)16,14(2)3)17-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3,(H,15,16)/p-1
SMILES Code
O=C([O-])C(CC)(N(C)C)OC1=CC=C(Cl)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 256.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: El-Nashar RM, Abdel Ghani NT, Hassan SM. Construction and performance characteristics of new ion selective electrodes based on carbon nanotubes for determination of meclofenoxate hydrochloride. Anal Chim Acta. 2012 Jun 12;730:99-111. doi: 10.1016/j.aca.2011.10.069. Epub 2011 Nov 15. PubMed PMID: 22632051. 2: Ni B, Zhang J, Zou J, Zhao W, Li J. A simple and sensitive HPLC method for quantification of the metabolin of meclofenoxate in human plasma. J Chromatogr Sci. 2010 May-Jun;48(5):353-7. PubMed PMID: 20515527. 3: Lazarova M, Georgiev V, Markovska V, Genkova M, Petkov VD. Effect of meclofenoxate on pentylenetetrazol kindling in albino rats. Acta Physiol Pharmacol Bulg. 1987;13(4):31-6. PubMed PMID: 3129904. 4: Neumann HJ. [The effect of meclofenoxate on the growth, fertility and number of offspring in Wistar rats]. Biomed Biochim Acta. 1985;44(2):289-300. German. PubMed PMID: 3924038. 5: Popova JS, Petkov VD. Effect of the combination of the benzodiazepine tranquilizer medazepam and the nootropic agent meclofenoxate on the activity of rat brain muscarinic receptors. Gen Pharmacol. 1990;21(6):927-30. PubMed PMID: 2279692. 6: Petkov VV, Grahovska T, Petkov VD, Konstantinova E. Effects of meclofenoxate on the level and turnover of biogenic monoamines in the rat brain. Arzneimittelforschung. 1985;35(12):1778-81. PubMed PMID: 2420335. 7: Mosharrof AH, Yonkov D, Petkov VD, Kambourova T, Todorov I, Alova L. Effects of meclofenoxate on learning and memory--dependence on the experimental conditions. Acta Physiol Pharmacol Bulg. 1986;12(3):7-14. PubMed PMID: 3101398. 8: Ludwig-Festl M, Gräter B, Bayreuther K. [Increase in cell metabolism in normal, diploid human glial cells in stationary cell cultures induced by meclofenoxate]. Arzneimittelforschung. 1983;33(4):495-501. German. PubMed PMID: 6191765. 9: Araman A, Caybaşi P, Güven KC. Stability of meclofenoxate hydrochloride in artificial gastric and intestinal media. Pharmazie. 1992 Feb;47(2):147. PubMed PMID: 1635926. 10: Takenaka F, Takeya N, Mitsufuji Y, Nakamura R, Tsutsumi E. [The effect of meclofenoxate (Lucidril) on the cerebral circulation of the dog]. Kumamoto Igakkai Zasshi. 1969 Feb 25;43(2):184-8. Japanese. PubMed PMID: 4388740. 11: Zou JJ, Ji HJ, Wu DW, Yao J, Hu Q, Xiao DW, Wang GJ. Bioequivalence and pharmacokinetic comparison of a single 200-mg dose of meclofenoxate hydrochloride capsule and tablet formulations in healthy Chinese adult male volunteers: a randomized sequence, open-label, two-period crossover study. Clin Ther. 2008 Sep;30(9):1651-7. doi: 10.1016/j.clinthera.2008.09.013. PubMed PMID: 18840370. 12: Meclofenoxate after eight years. Drug Ther Bull. 1972 Mar 3;10(5):18-9. PubMed PMID: 4402644. 13: Marcer D, Hopkins SM. The differential effects of meclofenoxate on memory loss in the elderly. Age Ageing. 1977 May;6(2):123-31. PubMed PMID: 329662. 14: Izumi K, Tominaga H, Koja T, Nomoto M, Shimizu T, Sonoda H, Imamura K, Igata A, Fukuda T. Meclofenoxate therapy in tardive dyskinesia: a preliminary report. Biol Psychiatry. 1986 Feb;21(2):151-60. PubMed PMID: 2868761. 15: Oliver JE, Restell M. Serial testing in assessing the effect of meclofenoxate on patients with memory defects. Br J Psychiatry. 1967 Feb;113(495):219-22. PubMed PMID: 4382246. 16: Voronina TA, Garibova TL, Trofimov SS, Sopyev ZhA, Petkov VD, Lazarova MB. Comparative studies on the influence of ONK (N(5-hydroxynicotinoil) glutamic acid), piracetam and meclofenoxate on the learning- and memory-impairing effect of scopolamine, clonidine, and methergoline. Acta Physiol Pharmacol Bulg. 1991;17(4):8-16. PubMed PMID: 1841522. 17: Wood PL, Péloquin A. Increases in choline levels in rat brain elicited by meclofenoxate. Neuropharmacology. 1982 Apr;21(4):349-54. PubMed PMID: 6806676. 18: Lazarova MB, Petkov VD, Markovska VL, Petkov VV, Mosharrof A. Effects of meclofenoxate and Extr. Rhodiolae roseae L. on electroconvulsive shock-impaired learning and memory in rats. Methods Find Exp Clin Pharmacol. 1986 Sep;8(9):547-52. PubMed PMID: 3095599. 19: Petkov VD, Popova JS. Effects of the nootropic agents adafenoxate, meclofenoxate and the acetylcholine precursor citicholine on the brain muscarinic receptors (experiments on rats). Acta Physiol Pharmacol Bulg. 1987;13(2):3-10. PubMed PMID: 3118641. 20: Yoshioka S, Aso Y, Uchiyama M. Kinetics of hydrolysis of meclofenoxate hydrochloride in human plasma. J Pharm Pharmacol. 1987 Mar;39(3):215-8. PubMed PMID: 2883287.