PWT33597 mesylate | CAS# | PI3K inhibitor

MedKoo Cat#: 205745 | Name: PWT33597 mesylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PWT33597, also known as VDC-597, is an orally bioavailable dual inhibitor of phosphatidylinositide 3-kinase (PI3K) alpha and mammalian target of rapamycin (mTOR) kinase with potential antineoplastic activity. PI3K alpha/mTOR dual inhibitor PWT33597 selectively inhibits both PI3K alpha kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells.

Chemical Structure

PWT33597 mesylate

CAS#1246203-36-0 (mesylate)

Theoretical Analysis

MedKoo Cat#: 205745

Name: PWT33597 mesylate

CAS#: 1246203-36-0 (mesylate)

Chemical Formula: C27H34F2N8O7S2

Exact Mass: 0.0000

Molecular Weight: 684.73

Elemental Analysis: C, 47.36; H, 5.01; F, 5.55; N, 16.36; O, 16.36; S, 9.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1246203-32-6 (free base) 1246203-36-0 (mesylate)

Synonym

PWT33597 ; PWT 33597; PWT33597; VDC-597; VDC597; VDC 597; PWT33597 mesylate

IUPAC/Chemical Name

N-(4-(4-(2-(difluoromethyl)-4-methoxy-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-2-(dimethylamino)ethane-1-sulfonamide mesylate

InChi Key

XSLUGEGXPCDRTN-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H30F2N8O4S.CH4O3S/c1-34(2)13-16-41(37,38)33-18-9-7-17(8-10-18)23-30-25(35-11-14-40-15-12-35)32-26(31-23)36-19-5-4-6-20(39-3)21(19)29-24(36)22(27)28;1-5(2,3)4/h4-10,22,33H,11-16H2,1-3H3;1H3,(H,2,3,4)

SMILES Code

O=S(CCN(C)C)(NC1=CC=C(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)C=C1)=O.OS(=O)(C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

PWT33597 is currently being developed by Pathyway Theraceuptics, which demonstrates excellent in vitro selectivity for its targets, with negligible activity against other lipid kinases, protein kinases and other pharmacologically relevant targets at biologically active concentrations. The compound achieves good distribution into tumors, robust pathway inhibition and excellent oral efficacy in multiple xenograft across varying genetic backgrounds. PWT33597 has an excellent DMPK and safety profile and is an attractive candidate for use as single agent and combination therapy. (source: http://pathwaytx.com/product_pipeline.html). Chemical structure was from https://figshare.com/articles/Chemical_structure_of_VDC-597_/6822143/1

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 684.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.