Balixafortide, also known as POL6326, is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. CXCR4 inhibitor POL6326 binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation. This may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types.
MedKoo Cat#: 205864
Name: Balixafortide TFA salt
CAS#: 1051366-32-5 (free base)
Chemical Formula: C90H121F9N24O27S2
Exact Mass: 0.0000
Molecular Weight: 2206.20
Elemental Analysis: C, 49.00; H, 5.53; F, 7.75; N, 15.24; O, 19.58; S, 2.91
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100.0 | 45.33 | |
| Water | 100.0 | 45.33 |
The following data is based on the product molecular weight 2,206.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
