MedKoo Cat#: 527881 | Name: WAY100635 Maleate
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WAY100635 Maleate is a potent, silent antagonist of serotonin 5-HT1A receptors.

Chemical Structure

WAY100635 Maleate
WAY100635 Maleate
CAS#1092679-51-0

Theoretical Analysis

MedKoo Cat#: 527881

Name: WAY100635 Maleate

CAS#: 1092679-51-0

Chemical Formula: C29H38N4O6

Exact Mass: 538.2791

Molecular Weight: 538.65

Elemental Analysis: C, 64.67; H, 7.11; N, 10.40; O, 17.82

Price and Availability

Size Price Availability Quantity
5mg USD 200.00
10mg USD 350.00
50mg USD 850.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
WAY 100635; WAY-100635; WAY100635 Maleate
IUPAC/Chemical Name
N-(2-(4-(2-Methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide Maleate
InChi Key
XIGAHNVCEFUYOV-BTJKTKAUSA-N
InChi Code
InChI=1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES Code
O=C(C1CCCCC1)N(CCN2CCN(C3=CC=CC=C3OC)CC2)C4=NC=CC=C4.O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 538.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pecikoza U, Lasica A, Nastić K, Dinić M, Jasnić N, Micov A, Đorđević J, Stepanović-Petrović R, Tomić M. Metformin reduces inflammatory nociception in mice through a serotonin-dependent mechanism. Eur J Pharmacol. 2025 Mar 15;991:177324. doi: 10.1016/j.ejphar.2025.177324. Epub 2025 Jan 30. PMID: 39892451. 2: Song MR, Huang MZ, Tao WJ, Yong Z, Su RB. Tandospirone prevents anesthetic- induced respiratory depression through 5-HT1A receptor activation in rats. Sci Rep. 2025 Jan 3;15(1):653. doi: 10.1038/s41598-024-84440-x. PMID: 39753642; PMCID: PMC11698729. 3: Depoortère R, Papp M, Gruca P, Litwa E, Lason M, Biała D, Newman-Tancredi A. The antidepressant-like activity of ketamine in the rat chronic mild stress model requires activation of cortical 5-HT1A receptors. Behav Pharmacol. 2024 Dec 16. doi: 10.1097/FBP.0000000000000809. Epub ahead of print. PMID: 39718040. 4: Girard P, Verleye M, Castagné V. Serotoninergic Mechanisms of Action in the Relaxant Properties of Saccharomyces boulardii CNCM I-745 on the Intestine. Dig Dis Sci. 2025 Jan;70(1):191-202. doi: 10.1007/s10620-024-08786-y. Epub 2024 Dec 11. PMID: 39661276; PMCID: PMC11761163. 5: Almeida-Souza TH, Silva RS, Franco HS, Santos LM, Melo JEC, Oliveira E Silva AM, Menezes EC, Santos JRD, Teixeira-Silva F, Goes TC, Marchioro M. Involvement of the serotonergic, GABAergic and glutamatergic systems of the rostral anterior cingulate cortex in the trait and state anxiety of adult male Wistar rats. Behav Brain Res. 2025 Feb 4;477:115298. doi: 10.1016/j.bbr.2024.115298. Epub 2024 Oct 19. PMID: 39433219. 6: Niitani K, Nishida R, Futami Y, Nishitani N, Deyama S, Kaneda K. Activation of ventral pallidum-projecting neurons in the nucleus accumbens via 5-HT2C receptor stimulation regulates motivation for wheel running in male mice. Neuropharmacology. 2024 Dec 15;261:110181. doi: 10.1016/j.neuropharm.2024.110181. Epub 2024 Oct 10. PMID: 39393590. 7: Pedrazzi JFC, Silva-Amaral D, Issy AC, Gomes FV, Crippa JA, Guimarães FS, Del Bel E. Cannabidiol attenuates prepulse inhibition disruption by facilitating TRPV1 and 5-HT1A receptor-mediated neurotransmission. Pharmacol Biochem Behav. 2024 Dec;245:173879. doi: 10.1016/j.pbb.2024.173879. Epub 2024 Sep 19. PMID: 39305939. 8: Takano M, Okada T, Shioda K, Yonekawa C, Suda S. Risperidone suppresses caffeine-induced hyperthermia and hyperactivity in rats. Neurosci Lett. 2024 Sep 25;840:137960. doi: 10.1016/j.neulet.2024.137960. Epub 2024 Sep 1. PMID: 39222834. 9: Yi M, Liu Z, Huang G, Wang H, Cao J, Wang Z, Wang M, Ke X. Behavioral dysregulation in Nile tilapia (Oreochromis niloticus, GIFT) post-Streptococcus agalactia infection: Role of the microbiota-gut-brain axis. Comp Biochem Physiol C Toxicol Pharmacol. 2024 Nov;285:110006. doi: 10.1016/j.cbpc.2024.110006. Epub 2024 Aug 16. PMID: 39154975. 10: Dudhabhate BB, Awathale SN, Choudhary AG, Subhedar NK, Kokare DM. Deep brain stimulation targeted at lateral hypothalamus-medial forebrain bundle reverses depressive-like symptoms and related cognitive deficits in rat: Role of serotoninergic system. Neuroscience. 2024 Sep 25;556:96-113. doi: 10.1016/j.neuroscience.2024.07.052. Epub 2024 Aug 3. PMID: 39103042. 11: Erfanparast A, Tamaddonfard S, Jafarzadeh-Balagafsheh P, Tamaddonfard E. Primary somatosensory cortex CB1 and 5‑HT1A receptors interaction in the penicillin model of epilepsy. Acta Neurobiol Exp (Wars). 2024 Jun 28;84(2):180-190. doi: 10.55782/ane-2024-2420. PMID: 39087841. 12: Sun Y, Chen Q, Cui W, Chen H, Zhao J, Rong J. Six-compound combo remedy ameliorates corticosterone-induced depressive behaviors in mice via targeting 5-hydroxytryptamine receptor 1A signaling. J Leukoc Biol. 2025 Feb 13;117(2):qiae167. doi: 10.1093/jleuko/qiae167. PMID: 39082750. 13: Kajikawa Y, Yokomi H, Narasaki S, Kamiya S, Miyoshi H, Kato T, Tsutsumi YM. Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Diabetes-Induced Neuropathic Pain. J Clin Med. 2024 Jul 22;13(14):4276. doi: 10.3390/jcm13144276. PMID: 39064315; PMCID: PMC11277645. 14: Zhu H, Wang L, Wang X, Yao Y, Zhou P, Su R. 5-hydroxytryptamine 2C/1A receptors modulate the biphasic dose response of the head twitch response and locomotor activity induced by DOM in mice. Psychopharmacology (Berl). 2024 Nov;241(11):2315-2330. doi: 10.1007/s00213-024-06635-4. Epub 2024 Jun 25. PMID: 38916640. 15: Zhang M, Qian X, Wei Z, Chen K, Ding H, Jia J, Li Y, Liu S, Yang K, Wang J, Chen H, Zhang W. Micro-Infusion of 5-HT1a Receptor Antagonists into the Ventral Subiculum Ameliorate MK-801 Induced Schizophrenia-Like Behavior in Rats. Neuroscience. 2024 Aug 6;552:115-125. doi: 10.1016/j.neuroscience.2024.06.010. Epub 2024 Jun 22. PMID: 38909674. 16: Zhu CP, Liu SQ, Wang KQ, Xiong HL, Aristu-Zabalza P, Boyer-Díaz Z, Feng JF, Song SH, Luo C, Chen WS, Zhang X, Dong WH, Gracia-Sancho J, Xie WF. Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension. Gastroenterology. 2024 Oct;167(5):993-1007. doi: 10.1053/j.gastro.2024.06.007. Epub 2024 Jun 19. PMID: 38906512. 17: Medeiros AC, Medeiros P, Pigatto GR, Maione S, Coimbra NC, de Freitas RL. Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: The role of prelimbic neocortex- hippocampal connections. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Aug 30;134:111039. doi: 10.1016/j.pnpbp.2024.111039. Epub 2024 May 24. PMID: 38797491. 18: Eken H, Bektas Turkmen N, Senel B, Arslan R. Examination of the effects of vitexin and vitexin-loaded solid lipid nanoparticles on neuropathic pain and possible mechanisms of action. Neuropharmacology. 2024 Aug 1;253:109961. doi: 10.1016/j.neuropharm.2024.109961. Epub 2024 Apr 22. PMID: 38657947. 19: Pires CS, da Rocha MJ, Presa MH, Zuge NP, Kuntz NEB, Godoi B, Bortolatto CF, Brüning CA. N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system. Psychopharmacology (Berl). 2024 Aug;241(8):1663-1678. doi: 10.1007/s00213-024-06588-8. Epub 2024 Apr 18. PMID: 38635075. 20: Liu Q, Deng Z, Chen H, Kim MS, Kim DH, Gu L, Lee JS, Yang Z. Changes in Induced-Antipredation Defense Traits and Transcriptome Regulations of Daphnia magna in Response to 5-HT1A Receptor Antagonist. Environ Sci Technol. 2024 Apr 30;58(17):7577-7587. doi: 10.1021/acs.est.3c10720. Epub 2024 Apr 17. PMID: 38630542.