AZ7976 | RXFP1 agaonist

MedKoo Cat#: 126561 | Name: AZ7976

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ7976 is a highly selective RXFP1 agonist with sub-nanomolar potency (hRXFP1cAMP pEC50,u > 10.5).

Chemical Structure

AZ7976

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 126561

Name: AZ7976

CAS#: N/A

Chemical Formula: C30H33F7N2O6S

Exact Mass: 682.1948

Molecular Weight: 682.65

Elemental Analysis: C, 52.78; H, 4.87; F, 19.48; N, 4.10; O, 14.06; S, 4.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AZ7976; AZ-7976; AZ 7976

IUPAC/Chemical Name

(1S,4s)-4-(2-fluoro-5-(((1S,2R,3S,4R)-3-((4-fluoro-3-(pentafluoro-l6-sulfaneyl)phenyl)carbamoyl)bicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methoxyphenoxy)-1-methylcyclohexane-1-carboxylic acid

InChi Key

CDRWWKJURUZOFS-XOGKYOQESA-N

InChi Code

InChI=1S/C30H33F7N2O6S/c1-30(29(42)43)9-7-18(8-10-30)45-23-13-19(22(44-2)14-21(23)32)27(40)39-26-16-4-3-15(11-16)25(26)28(41)38-17-5-6-20(31)24(12-17)46(33,34,35,36)37/h5-6,12-16,18,25-26H,3-4,7-11H2,1-2H3,(H,38,41)(H,39,40)(H,42,43)/t15-,16+,18-,25+,26-,30+/m1/s1

SMILES Code

C[C@]1(C(O)=O)CC[C@@H](OC2=C(F)C=C(OC)C(C(N[C@@H]3[C@H](C4)CC[C@H]4[C@@H]3C(NC5=CC=C(F)C(S(F)(F)(F)(F)F)=C5)=O)=O)=C2)CC1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 682.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Granberg KL, Sakamaki S, Fuchigami R, Niwa Y, Fujio M, Kato H, Bergström F, Larsson N, Persson M, Villar IC, Fujita T, Sugikawa E, Althage M, Yano N, Yokoyama Y, Kimura J, Lal M, Mochida H. Identification of Novel Series of Potent and Selective Relaxin Family Peptide Receptor 1 (RXFP1) Agonists. J Med Chem. 2024 Mar 19. doi: 10.1021/acs.jmedchem.3c02183. Epub ahead of print. PMID: 38502780. 2: Granberg KL, Sakamaki S, Larsson N, Bergström F, Fuchigami R, Niwa Y, Ryberg E, Backmark A, Kato H, Miyazaki S, Iguchi K, Sakamoto T, Persson M, Idei A, Prieto Garcia L, Villar IC, Gradén H, Bergonzini G, Arvidsson T, Fujita T, Althage M, Ulander J, Kimura J, Yoneda H, Fjellström O, Mochida H, Lal M. Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure. J Med Chem. 2024 Mar 19. doi: 10.1021/acs.jmedchem.3c02184. Epub ahead of print. PMID: 38502782.