DCPG | mGluR8 agonist | class III metabotropic glutamate receptor 8 | CAS#201730-11-2

MedKoo Cat#: 127937 | Name: DCPG

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DCPG is a selective agonist of the class III metabotropic glutamate receptor 8 (mGluR8), with an EC50 value of 31 nM for inhibiting forskolin-stimulated cAMP formation in AV12-664 cells expressing human mGluR8.

Chemical Structure

DCPG

CAS#201730-11-2

Theoretical Analysis

MedKoo Cat#: 127937

Name: DCPG

CAS#: 201730-11-2

Chemical Formula: C10H9NO6

Exact Mass: 239.0430

Molecular Weight: 239.18

Elemental Analysis: C, 50.22; H, 3.79; N, 5.86; O, 40.13

Price and Availability

Size	Price	Availability
25mg	USD 350.00	2 Weeks
100mg	USD 1,250.00	2 Weeks
1g	USD 4,250.00	2 Weeks

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Related CAS #

No Data

Synonym

DCPG; (S)-3,4-DCPG;

IUPAC/Chemical Name

4-[(S)-aminocarboxymethyl]-1,2-benzenedicarboxylic acid

InChi Key

IJVMOGKBEVRBPP-ZETCQYMHSA-N

InChi Code

InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1

SMILES Code

O=C(C1=CC=C([C@H](N)C(O)=O)C=C1C(O)=O)O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Biological target:

DCPG is a selective agonist of the class III metabotropic glutamate receptor 8 (mGluR8), with an EC50 value of 31 nM

In vitro activity:

We thus investigated the effect of the selective mGlu8 receptor agonist (S)-3,4-dicarboxyphenylglycine (DCPG) on excitatory synaptic transmission in the superficial superior colliculus (SC) using an in vitro slice preparation of the rat SC. Field EPSPs evoked by optic tract stimulation under conditions of GABA receptor blockade were reduced by DCPG by up to 67.8+/-5.46% (EC(50) 1.25+/-0.56 microM), and this effect could be antagonised by LY341495 at a concentration (300 nM) known to be effective at mGlu8 receptors but not at mGlu4 or mGlu7 receptors. Reference: 1: Pothecary CA, Jane DE, Salt TE. Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG. Neuropharmacology. 2002 Aug;43(2):231-4. doi: 10.1016/s0028-3908(02)00077-1. PMID: 12213277.

In vivo activity:

In the present study we examined the effect of the highly specific mGluR8 agonist (S)-3,4-DCPG on conditioned fear in vivo measuring fear-potentiated startle. Both, acquisition and expression of conditioned fear were dose-dependently inhibited by (S)-3,4-DCPG injections into the amygdala. Reference: Schmid S, Fendt M. Effects of the mGluR8 agonist (S)-3,4-DCPG in the lateral amygdala on acquisition/expression of fear-potentiated startle, synaptic transmission, and plasticity. Neuropharmacology. 2006 Feb;50(2):154-64. doi: 10.1016/j.neuropharm.2005.08.002. Epub 2005 Sep 26. PMID: 16188284.

	Solvent	mg/mL	mM
Solubility
	DMSO	20.0	83.62

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 239.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.