Laduviglusib, also known as CHIR-99021 and CT99021, is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM.
MedKoo Cat#: 124673
Name: Laduviglusib HCl
CAS#: 2109414-84-6 (2HCl)
Chemical Formula: C22H20Cl4N8
Exact Mass: 536.0600
Molecular Weight: 538.26
Elemental Analysis: C, 49.09; H, 3.75; Cl, 26.34; N, 20.82
The following data is based on the product molecular weight 538.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
