RP-6685 is a potent, selective, and orally bioavailable Polθ inhibitor that showed in vivo efficacy in an HCT116 BRCA2−/− mouse tumor xenograft model. RP-6685 was extremely potent with an IC50 of 550 pM against the pol activity of full-length Polθ and inactive on the ATPase activity. RP-6685 displayed a favorable PK profile with good oral bioavailability in mouse.
MedKoo Cat#: 126357
Name: RP-6685 HCl
CAS#: RP-6685 HCl
Chemical Formula: C22H16Cl2F7N5O
Exact Mass: 497.1087
Molecular Weight: 570.29
Elemental Analysis: C, 46.33; H, 2.83; Cl, 12.43; F, 23.32; N, 12.28; O, 2.81
The following data is based on the product molecular weight 570.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
