UC-1V150 | TLR7 agonist | CAS#927822-45-5

MedKoo Cat#: 126320 | Name: UC-1V150

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UC-1V150 is a TLR7 agonist.

Chemical Structure

UC-1V150

CAS#927822-45-5

Theoretical Analysis

MedKoo Cat#: 126320

Name: UC-1V150

CAS#: 927822-45-5

Chemical Formula: C16H17N5O4

Exact Mass: 343.1281

Molecular Weight: 343.34

Elemental Analysis: C, 55.97; H, 4.99; N, 20.40; O, 18.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

UC-1V150; UC 1V150; UC1V150

IUPAC/Chemical Name

4-((6-amino-2-(2-methoxyethoxy)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)benzaldehyde

InChi Key

SHNIBVWXUOEWTA-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H17N5O4/c1-24-6-7-25-15-19-13(17)12-14(20-15)21(16(23)18-12)8-10-2-4-11(9-22)5-3-10/h2-5,9H,6-8H2,1H3,(H,18,23)(H2,17,19,20)

SMILES Code

O=CC1=CC=C(CN2C(NC3=C2N=C(OCCOC)N=C3N)=O)C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 343.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dahal LN, Gadd A, Edwards AD, Cragg MS, Beers SA. UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion. Scand J Immunol. 2018 Jun;87(6):e12666. doi: 10.1111/sji.12666. Epub 2018 May 6. PMID: 29667229. 2: Gadd AJ, Greco F, Cobb AJ, Edwards AD. Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity. Bioconjug Chem. 2015 Aug 19;26(8):1743-52. doi: 10.1021/acs.bioconjchem.5b00302. Epub 2015 Jul 16. PMID: 26133029. 3: Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam HB, Carson DA. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3990-5. doi: 10.1073/pnas.0611624104. Epub 2007 Feb 21. PMID: 17360465; PMCID: PMC1820696.