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MedKoo Cat#: 126318 | Name: CL097

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CL097 is a TLR7 agonist.

Chemical Structure

CL097
CL097
CAS#1026249-18-2

Theoretical Analysis

MedKoo Cat#: 126318

Name: CL097

CAS#: 1026249-18-2

Chemical Formula: C13H14N4O

Exact Mass: 242.1168

Molecular Weight: 242.28

Elemental Analysis: C, 64.45; H, 5.82; N, 23.13; O, 6.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CL097; CL-097; CL 097
IUPAC/Chemical Name
2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine
InChi Key
DEVCLHVFELRPIU-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H14N4O/c1-2-18-7-10-16-11-8-5-3-4-6-9(8)15-13(14)12(11)17-10/h3-6H,2,7H2,1H3,(H2,14,15)(H,16,17)
SMILES Code
CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 242.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Petricevic B, Wessner B, Sachet M, Vrbanec D, Spittler A, Bergmann M. CL097, a TLR7/8 ligand, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression. Shock. 2009 Nov;32(5):484-90. doi: 10.1097/SHK.0b013e3181a5ac8a. PMID: 19333135. 2: Wu J, Li S, Li T, Lv X, Zhang M, Zang G, Qi C, Liu YJ, Xu L, Chen J. pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG. J Immunol Res. 2019 Apr 9;2019:1749803. doi: 10.1155/2019/1749803. PMID: 31093508; PMCID: PMC6481147. 3: Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27. PMID: 27692612. 4: Makni-Maalej K, Boussetta T, Hurtado-Nedelec M, Belambri SA, Gougerot- Pocidalo MA, El-Benna J. The TLR7/8 agonist CL097 primes N-formyl-methionyl- leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. J Immunol. 2012 Nov 1;189(9):4657-65. doi: 10.4049/jimmunol.1201007. Epub 2012 Sep 21. PMID: 23002436. 5: Xiao Q, Li X, Sun D, Yi H, Lu X, Nian H. TLR7 Engagement on Dendritic Cells Enhances Autoreactive Th17 Responses via Activation of ERK. J Immunol. 2016 Nov 15;197(10):3820-3830. doi: 10.4049/jimmunol.1600333. Epub 2016 Oct 19. PMID: 27798152. 6: Tajuddin T, Ryan EJ, Norris S, Hegarty JE, O'Farrelly C. Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist. J Gastroenterol Hepatol. 2010 Dec;25(12):1883-90. doi: 10.1111/j.1440-1746.2010.06281.x. PMID: 21092001.

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