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MedKoo Cat#: 412737 | Name: CGP 55845

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 55845 is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively).

Chemical Structure

CGP 55845
CGP 55845
CAS#150175-54-5 (free base)

Theoretical Analysis

MedKoo Cat#: 412737

Name: CGP 55845

CAS#: 150175-54-5 (free base)

Chemical Formula: C18H22Cl2NO3P

Exact Mass: 401.0714

Molecular Weight: 402.25

Elemental Analysis: C, 53.75; H, 5.51; Cl, 17.63; N, 3.48; O, 11.93; P, 7.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
149184-22-5 (HCl) 150175-54-5 (free base)
Synonym
CGP 55845; CGP-55845; CGP55845
IUPAC/Chemical Name
Phosphinic acid, ((2S)-3-(((1S)-1-(3,4-dichlorophenyl)ethyl)amino)-2- hydroxypropyl)(phenylmethyl)-
InChi Key
ZODSPDOOCZZEIM-BBRMVZONSA-N
InChi Code
InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
SMILES Code
O=P(CC1=CC=CC=C1)(C[C@@H](O)CN[C@H](C2=CC=C(Cl)C(Cl)=C2)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gillani Q, Ali M, Iqbal F. Effect of GABAB receptor antagonists (CGP 35348 and CGP 55845) on serum interleukin 6 and 18 concentrations in albino mice following neonatal hypoxia ischemia insult. Pak J Pharm Sci. 2016 Sep;29(5):1503-1508. PMID: 27731803. 2: Gillani QA, Akbar A, Ali M, Iqbal F. Gender-specific effects of CGP 55845, GABAB receptor antagonist, on neuromuscular coordination, learning and memory formation in albino mouse following neonatal hypoxia-ischemia insult. Neurol Sci. 2015 Jun;36(6):961-9. doi: 10.1007/s10072-015-2205-2. Epub 2015 Apr 7. PMID: 25847084. 3: Salah A, Perkins KL. Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices. Neuropharmacology. 2008 Jul;55(1):47-54. doi: 10.1016/j.neuropharm.2008.04.010. Epub 2008 Apr 23. PMID: 18538357; PMCID: PMC2774743. 4: Lenina O, Petrov K, Kovyazina I, Malomouzh A. Enhancement of mouse diaphragm contractility in the presence of antagonists of GABAA and GABAB receptors. Exp Physiol. 2019 Jul;104(7):1004-1010. doi: 10.1113/EP087611. Epub 2019 May 27. PMID: 31074160. 5: Svejgaard B, Andreasen M, Nedergaard S. Role of GABAB receptors in proepileptic and antiepileptic effects of an applied electric field in rat hippocampus in vitro. Brain Res. 2019 May 1;1710:157-162. doi: 10.1016/j.brainres.2018.12.043. Epub 2018 Dec 29. PMID: 30599137. 6: Lang M, Moradi-Chameh H, Zahid T, Gane J, Wu C, Valiante T, Zhang L. Regulating hippocampal hyperexcitability through GABAB Receptors. Physiol Rep. 2014 Apr 22;2(4):e00278. doi: 10.14814/phy2.278. PMID: 24771688; PMCID: PMC4001873. 7: Salio C, Merighi A, Bardoni R. GABAB receptors-mediated tonic inhibition of glutamate release from Aβ fibers in rat laminae III/IV of the spinal cord dorsal horn. Mol Pain. 2017 Jan-Dec;13:1744806917710041. doi: 10.1177/1744806917710041. PMID: 28565998; PMCID: PMC5456036. 8: Luo F, Kiss ZH. Cholinergic mechanisms of high-frequency stimulation in entopeduncular nucleus. J Neurophysiol. 2016 Jan 1;115(1):60-7. doi: 10.1152/jn.00269.2015. Epub 2015 Sep 2. PMID: 26334006; PMCID: PMC4760488. 9: Buonomano DV, Merzenich MM. Net interaction between different forms of short- term synaptic plasticity and slow-IPSPs in the hippocampus and auditory cortex. J Neurophysiol. 1998 Oct;80(4):1765-74. doi: 10.1152/jn.1998.80.4.1765. PMID: 9772237. 10: Selten MM, Meyer F, Ba W, Vallès A, Maas DA, Negwer M, Eijsink VD, van Vugt RWM, van Hulten JA, van Bakel NHM, Roosen J, van der Linden RJ, Schubert D, Verheij MMM, Kasri NN, Martens GJM. Increased GABAB receptor signaling in a rat model for schizophrenia. Sci Rep. 2016 Sep 30;6:34240. doi: 10.1038/srep34240. PMID: 27687783; PMCID: PMC5043235.