Synonym
SPIROGERMANIUM HYDROCHLORIDE; SPIROGERMANIUM DIHYDROCHLORIDE; NSC-192965; NSC192965; NSC 192965
IUPAC/Chemical Name
3-(8,8-diethyl-2-aza-8-germaspiro[4.5]decan-2-yl)-N,N-dimethylpropan-1-amine dihydrochloride
InChi Key
GRLUHXSUZYFZCW-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H36GeN2.2ClH/c1-5-18(6-2)11-8-17(9-12-18)10-15-20(16-17)14-7-13-19(3)4;;/h5-16H2,1-4H3;2*1H
SMILES Code
Cl.Cl.CC[Ge]1(CC)CCC2(CCN(CCCN(C)C)C2)CC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
414.04
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Slavik M, Blanc O, Davis J. Spirogermanium: a new investigational drug of
novel structure and lack of bone marrow toxicity. Invest New Drugs.
1983;1(3):225-34. doi: 10.1007/BF00208894. PMID: 6678870.
2: DiMartino MJ, Lee JC, Badger AM, Muirhead KA, Mirabelli CK, Hanna N.
Antiarthritic and immunoregulatory activity of spirogermanium. J Pharmacol Exp
Ther. 1986 Jan;236(1):103-10. PMID: 2934544.
3: Schwartz GN, Biegel JA, Fisher B, Klein I. Spirogermanium: effects on
hematopoietic stem cells and survival of normal and tumor-bearing mice. Proc Soc
Exp Biol Med. 1983 Jun;173(2):176-80. doi: 10.3181/00379727-173-41627. PMID:
6866997.
4: Hill BT, Whelan RD. Spirogermanium--a novel antitumour agent expressing a
lack of cross-resistance in vitro with a range of 'standard' antitumour drugs.
Invest New Drugs. 1986;4(4):359-65. doi: 10.1007/BF00173508. PMID: 3583643.
5: Mirabelli CK, Badger AM, Sung CP, Hillegass L, Sung CM, Johnson RK, Picker D,
Schwartz D, Dorman J, Martellucci S. Pharmacological activities of
spirogermanium and other structurally related azaspiranes: effects on tumor cell
and macrophage functions. Anticancer Drug Des. 1989 Mar;3(4):231-42. PMID:
2930625.
6: Mrema JE, Slavik M, Davis J. Spirogermanium: a new drug with antimalarial
activity against chloroquine-resistant Plasmodium falciparum. Int J Clin
Pharmacol Ther Toxicol. 1983 Apr;21(4):167-71. PMID: 6345410.
