ZNL0325 is a pyrazolopyrimidine-based covalent probe. ZNL0325 demonstrates an alternative binding mode for kinases. ZNL0325 exhibits a flipped binding mode where the C3 position is oriented toward the ribose binding pocket. ZNL0325 and its analogues feature an acrylamide side chain at the C3 position which is capable of forming a covalent bond with multiple kinases that possess a cysteine at the αD-1 position including BTK, EGFR, BLK, and JAK3.
MedKoo Cat#: 126165
Name: ZNL0325
CAS#: N/A
Chemical Formula: C15H20N6O2
Exact Mass: 316.1648
Molecular Weight: 316.37
Elemental Analysis: C, 56.95; H, 6.37; N, 26.56; O, 10.11
The following data is based on the product molecular weight 316.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
