MedKoo Cat#: 126119 | Name: GSK840
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK840 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 0.3 nM).

Chemical Structure

GSK840
GSK840
CAS#2361146-30-5

Theoretical Analysis

MedKoo Cat#: 126119

Name: GSK840

CAS#: 2361146-30-5

Chemical Formula: C21H23N3O3

Exact Mass: 365.1739

Molecular Weight: 365.43

Elemental Analysis: C, 69.02; H, 6.34; N, 11.50; O, 13.13

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
25mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
GSK840; GSK-840; GSK 840
IUPAC/Chemical Name
tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate
InChi Key
UGTLDBJIOSYXRR-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H23N3O3/c1-21(2,3)27-19(25)11-14-5-8-16(9-6-14)24-13-23-17-12-15(20(26)22-4)7-10-18(17)24/h5-10,12-13H,11H2,1-4H3,(H,22,26)
SMILES Code
O=C(C1=CC=C2N(C(C=C3)=CC=C3CC(OC(C)(C)C)=O)C=NC2=C1)NC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 365.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Feng Y, Hu C, Cui K, Fan M, Xiang W, Ye D, Shi Y, Ye H, Bai X, Wei Y, Xu Y, Huang J. GSK840 Alleviates Retinal Neuronal Injury by Inhibiting RIPK3/MLKL-Mediated RGC Necroptosis After Ischemia/Reperfusion. Invest Ophthalmol Vis Sci. 2023 Nov 1;64(14):42. doi: 10.1167/iovs.64.14.42. PMID: 38015174; PMCID: PMC10691386.